Intravitreal topotecan 90 μg for recurrent solid retinoblastoma tumors is effective and not toxic Journal Article
| Authors: | Abramson, D. H.; Francis, J. H. |
| Article Title: | Intravitreal topotecan 90 μg for recurrent solid retinoblastoma tumors is effective and not toxic |
| Abstract: | The authors report on the safety and efficacy of 90 μg/0.18 cc of intravitreal topotecan for recurrent solid retinal tumors in retinoblastoma. Topotecan 90 μg was injected intravitreally in three retinoblastoma cases that progressed after prior therapy. Safety was monitored with retinal examinations under anesthesia and 30-Hz flicker electroretinograms. There was complete disappearance of recurrent retinal tumors with only one injection of 90 μg of intravitreal topotecan without any toxicity. Intravitreal 90 μg caused prompt regression of retinal tumors in three children who had progression of their retinoblastoma after prior therapy. No toxicity was seen. This is the first report of intravitreal 90 μg in humans and the first report of responses of retinal tumors from intravitreal topotrecan. [J Pediatr Ophthalmol Strabismus. 2023;60(2):e16-e18.] © 2023 Slack Incorporated. All rights reserved. |
| Keywords: | child; topotecan; neoplasm recurrence, local; melphalan; retinoblastoma; retina tumor; retinal neoplasms; tumor recurrence; humans; human; intravitreal injections; intravitreal drug administration |
| Journal Title: | Journal of Pediatric Ophthalmology and Strabismus |
| Volume: | 60 |
| Issue: | 2 |
| ISSN: | 0191-3913 |
| Publisher: | SLACK, Inc. |
| Date Published: | 2023-03-01 |
| Start Page: | e16 |
| End Page: | e18 |
| Language: | English |
| DOI: | 10.3928/01913913-20230110-01 |
| PUBMED: | 36975114 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 May 2023 -- Source: Scopus |
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