Small cell carcinoma of the ovary, hypercalcemic type Book Section
| Authors: | Levine, D. A.; Filho, D. C.; Kertowidjojo, E.; Chui, M. H. |
| Editors: | Frumovitz, M.; Leitao, M. M. Jr; Ramalingam, P. |
| Article/Chapter Title: | Small cell carcinoma of the ovary, hypercalcemic type |
| Abstract: | Small cell carcinoma of the ovary, hypercalcemic type (SCCOHT) is a rare and highly aggressive malignancy that predominantly affects young women in their second and third decades of life. The reported survival is only 55% for stage I tumors, and long-term survival is uncommon with more advanced disease. SCCOHT is characterized by monogenic loss-of-function mutations in SMARCA4. The mechanisms of tumorigenesis in SCCOHT remain poorly understood, the survival rate is low, and effective treatments are needed. © 2023 Elsevier Inc. All rights reserved. |
| Keywords: | ovarian cancer; small cell carcinoma; hypercalcemic type; chromatin remodeling; smarca4 |
| Book Title: | Diagnosis and Treatment of Rare Gynecologic Cancers |
| ISBN: | 978-0-323-82938-0 |
| Publisher: | Elsevier Inc. |
| Publication Place: | Amsterdam, Netherlands |
| Date Published: | 2023-01-01 |
| Start Page: | 109 |
| End Page: | 119 |
| Language: | English |
| DOI: | 10.1016/b978-0-323-82938-0.00007-0 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 7, part of "Section A: Ovarian cancers" -- Export Date: 1 May 2023 -- Source: Scopus |
