Mucinous ovarian carcinomas Book Section
| Authors: | Kim, S. H.; O’Cearbhaill, R. E.; Ramalingam, P.; Mueller, J. J. |
| Editors: | Frumovitz, M.; Leitao, M. M. Jr; Ramalingam, P. |
| Article/Chapter Title: | Mucinous ovarian carcinomas |
| Abstract: | Primary mucinous ovarian carcinomas (are a rare tumor type, accounting for less than 3% of epithelial ovarian carcinomas (Heinzelmann-Schwarz et al., 2006; Seidman et al., 2004; Shimada et al., 2009; Torre et al., 2018)). The majority of cases are diagnosed at an early stage and are therefore often associated with a favorable prognosis following surgical resection (Morice et al., 2019; Prat et al., 2018). However, patients with advanced-stage mucinous ovarian carcinoma have a worse progression-free survival and overall survival compared to advanced-stage high-grade serous ovarian carcinomas due to relative resistance to platinum-based chemotherapy (Prat et al., 2018; Hess et al., 2004; Kurnit et al., 2019; Mackay et al., 2010; Pectasides et al., 2005; Peres et al., 2019; Pignata et al., 2008; Schlappe et al., 2019; Simons et al., 2015; Zaino et al., 2011). Historically, the treatment of these rare tumors has been extrapolated from clinical trials focusing on the treatment of nonmucinous ovarian cancers. Given the biological and molecular similarities to gastrointestinal (GI) carcinomas, studies have evaluated the efficacy of GI-based chemotherapy; however, data supporting the use of these regimens is limited (Kurnit et al., 2019; Schlappe et al., 2019; Gore et al., 2019). Targeted therapeutics may be the future for the treatment of advanced or recurrent mucinous ovarian carcinoma (Gorringe et al., 2020). © 2023 Elsevier Inc. All rights reserved. |
| Keywords: | genetics; treatment; pathology; diagnosis; mucinous ovarian carcinoma |
| Book Title: | Diagnosis and Treatment of Rare Gynecologic Cancers |
| ISBN: | 978-0-323-82938-0 |
| Publisher: | Elsevier Inc. |
| Publication Place: | Amsterdam, Netherlands |
| Date Published: | 2023-01-01 |
| Start Page: | 77 |
| End Page: | 93 |
| Language: | English |
| DOI: | 10.1016/b978-0-323-82938-0.00005-7 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 5, part of "Section A: Ovarian cancers" -- Export Date: 1 May 2023 -- Source: Scopus |
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