PIK3CA hotspot mutation generates a shared neoantigen targetable by TCR gene therapy Editorial
| Authors: | Klebanoff, C. A.; Chandran, S. S. |
| Title: | PIK3CA hotspot mutation generates a shared neoantigen targetable by TCR gene therapy |
| Abstract: | PIK3CA gain-of-function mutations are among the most common alterations in human solid cancers. Through the use of stimulation-induced functional T cell receptor (TCR) sequencing (SIFT-seq), a panel of TCRs that bind a mutant PI3K alpha shared neoantigen was identified, including a potential clinical candidate that engages cancer cells via a distinctive CDR3 beta loop. |
| Journal Title: | Nature Medicine |
| Volume: | 28 |
| Issue: | 5 |
| ISSN: | 1078-8956 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2022-05-01 |
| Start Page: | 907 |
| End Page: | 908 |
| Language: | English |
| ACCESSION: | WOS:000788453200001 |
| DOI: | 10.1038/s41591-022-01806-2 |
| PROVIDER: | wos |
| PUBMED: | 35484265 |
| Notes: | This is a summary of the article at DOI: 10.1038/s41591-022-01786-3 -- Source: Wos |
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