Molecularly targeted epigenetic therapy with mocetinostat in relapsed and refractory non-Hodgkin lymphoma with CREBBP or EP300 mutations: An open label phase II study Research Letter


Authors: Qualls, D.; Noy, A.; Straus, D.; Matasar, M.; Moskowitz, C.; Seshan, V.; Dogan, A.; Salles, G.; Younes, A.; Zelenetz, A. D.; Batlevi, C. L.
Title: Molecularly targeted epigenetic therapy with mocetinostat in relapsed and refractory non-Hodgkin lymphoma with CREBBP or EP300 mutations: An open label phase II study
Keywords: adult; controlled study; event free survival; aged; middle aged; major clinical study; genetics; mutation; histone deacetylase inhibitor; clinical trial; fatigue; cancer recurrence; diarrhea; drug withdrawal; letter; multiple cycle treatment; phase 2 clinical trial; neoplasm recurrence, local; nausea; antineoplastic activity; rash; nonhodgkin lymphoma; lymphoma, non-hodgkin; epigenetics; epigenesis, genetic; tumor recurrence; vorinostat; genetic screening; genetic epigenesis; panobinostat; follicular lymphoma; molecularly targeted therapy; mocetinostat; e1a associated p300 protein; overall response rate; e1a-associated p300 protein; diffuse large b cell lymphoma; histone acetyltransferase; ep300 protein, human; creb-binding protein; cyclic amp responsive element binding protein binding protein; high throughput sequencing; gain of function mutation; refractory disease; abexinostat; very elderly; humans; human; male; female; crebbp protein, human; tazemetostat; monoclonal antibody therapy; ecog performance status; chemiluminescence immunoassay
Journal Title: Leukemia and Lymphoma
Volume: 64
Issue: 3
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2023-01-01
Start Page: 738
End Page: 741
Language: English
DOI: 10.1080/10428194.2022.2164194
PUBMED: 36642966
PROVIDER: scopus
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Connie Batlevi -- Source: Scopus
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MSK Authors
  1. Venkatraman Ennapadam Seshan
    382 Seshan
  2. Craig Moskowitz
    407 Moskowitz
  3. Ariela Noy
    351 Noy
  4. Andrew D Zelenetz
    767 Zelenetz
  5. Matthew J Matasar
    289 Matasar
  6. David J Straus
    356 Straus
  7. Connie Wing-Ching Lee Batlevi
    176 Batlevi
  8. Anas Younes
    319 Younes
  9. Ahmet Dogan
    454 Dogan
  10. Gilles Andre Salles
    269 Salles
  11. David Augustus Qualls
    20 Qualls