Secondary antibody deficiency in chronic lymphocytic leukemia and non-Hodgkin lymphoma: Recommendations from an international expert panel Review

  


Authors: Jolles, S.; Giralt, S.; Kerre, T.; Lazarus, H. M.; Mustafa, S. S.; Papanicolaou, G. A.; Reiser, M.; Ria, R.; Vinh, D. C.; Wingard, J. R.
Review Title: Secondary antibody deficiency in chronic lymphocytic leukemia and non-Hodgkin lymphoma: Recommendations from an international expert panel
Abstract: Lymphoid hematologic malignancies (HMs) and their treatment may result in secondary antibody deficiency (SAD), which is associated with an increased risk and susceptibility for recurrent and/or severe infections. Infection-related morbidity and mortality are major concerns when managing patients with HMs. The HM treatment landscape continues to evolve at a rapid pace, thereby necessitating the need for up-to-date guidance on how best to recognize, diagnose, treat, and monitor patients at risk of developing SAD. This consensus review, from a panel of international experts, aims to address this challenge by raising awareness of SAD and providing practical recommendations on SAD diagnosis and management. SAD evaluation is recommended at diagnosis of lymphoid HM in all patients, irrespective of infection history, to risk-stratify and define disease versus treatment-related SAD. Our recommendations promote a proactive and individualized approach to patient management to reduce infection risk and improve outcomes. © 2022 The Authors
Keywords: hypogammaglobulinemia; chronic lymphocytic leukemia (cll); non-hodgkin lymphoma (nhl); hematologic malignancy (hm); ig replacement therapy (igrt); secondary antibody deficiency (sad)
Journal Title: Blood Reviews
Volume: 58
ISSN: 0268-960X
Publisher: Churchill Livingstone  
Date Published: 2023-03-01
Start Page: 101020
Language: English
DOI: 10.1016/j.blre.2022.101020
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85140581208&doi=10.1016%2fj.blre.2022.101020&partnerID=40&md5=7c0190a14863e02e6a39739c2615cfa8
Notes: Review -- Source: Scopus
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MSK Authors
  1. Sergio Andres Giralt
    1050 Giralt
  2. Genovefa A Papanicolaou
    238 Papanicolaou
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