Confocal microscopy for diagnosis and management of cutaneous malignancies: Clinical impacts and innovation Review


Authors: Atak, M. F.; Farabi, B.; Navarrete-Dechent, C.; Rubinstein, G.; Rajadhyaksha, M.; Jain, M.
Review Title: Confocal microscopy for diagnosis and management of cutaneous malignancies: Clinical impacts and innovation
Abstract: Cutaneous malignancies are common malignancies worldwide, with rising incidence. Most skin cancers, including melanoma, can be cured if diagnosed correctly at an early stage. Thus, millions of biopsies are performed annually, posing a major economic burden. Non-invasive skin imaging techniques can aid in early diagnosis and save unnecessary benign biopsies. In this review article, we will discuss in vivo and ex vivo confocal microscopy (CM) techniques that are currently being utilized in dermatology clinics for skin cancer diagnosis. We will discuss their current applications and clinical impact. Additionally, we will provide a comprehensive review of the advances in the field of CM, including multi-modal approaches, the integration of fluorescent targeted dyes, and the role of artificial intelligence for improved diagnosis and management. © 2023 by the authors.
Keywords: reflectance confocal microscopy; confocal microscopy; in vivo confocal microscopy; ex vivo confocal microscopy; clinical impacts in confocal microscopy in cutaneous oncology; innovations and advances in confocal microscopy in cutaneous oncology
Journal Title: Diagnostics
Volume: 13
Issue: 5
ISSN: 2075-4418
Publisher: MDPI  
Date Published: 2023-03-01
Start Page: 854
Language: English
DOI: 10.3390/diagnostics13050854
PROVIDER: scopus
PMCID: PMC10001140
PUBMED: 36899999
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK author: Manu Jain -- Source: Scopus
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  1. Manu   Jain
    76 Jain