Unraveling barriers to iPSC-derived CAR-T cell differentiation Editorial

  


Authors: van der Stegen, S. J. C.; Rivière, I.
Title: Unraveling barriers to iPSC-derived CAR-T cell differentiation
Abstract: The generation of off-the-shelf CAR-T cells from TiPSCs has been hindered by the difficulty to recapitulate adaptive T cell development and lower therapeutic efficacy compared to peripheral blood CAR-T cells. Ueda et al. address these issues in a triple-engineering strategy, combining optimized CAR expression with cytolytic and persistence enhancements. © 2023 Elsevier Inc.
Keywords: note; t lymphocyte; phenotype; cell death; in vivo study; cell differentiation; antineoplastic activity; antigen specificity; lymphocyte; induced pluripotent stem cells; engineering; innate lymphoid cell; induced pluripotent stem cell; human; chimeric antigen receptor t-cell immunotherapy; receptors, chimeric antigen
Journal Title: Cell Stem Cell
Volume: 30
Issue: 3
ISSN: 1934-5909
Publisher: Cell Press  
Date Published: 2023-03-02
Start Page: 248
End Page: 249
Language: English
DOI: 10.1016/j.stem.2023.02.004
PUBMED: 36868193
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149062898&doi=10.1016%2fj.stem.2023.02.004&partnerID=40&md5=9947cd3c11999ceb9650a511de2b8f9f
Notes: Note -- Source: Scopus
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MSK Authors
  1. Isabelle C Riviere
    240 Riviere
  2. Sjoukje Judith Catherina van der Stegen
    26 van der Stegen
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