Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine Journal Article
| Authors: | Burns, A. A.; Vider, J.; Ow, H.; Herz, E.; Penate-Medina, O.; Baumgart, M.; Larson, S. M.; Wiesner, U.; Bradbury, M. |
| Article Title: | Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine |
| Abstract: | The development of molecularly targeted probes that exhibit high biostability, biocompatibility, and efficient clearance profiles is key to optimizing biodistribution and transport across biological barriers. Further, coupling probes designed to meet these criteria with high-sensitivity, quantitative imaging strategies is mandatory for ensuring early in vivo tumor detection and timely treatment response. These challenges have often only been examined individually, impeding the clinical translation of fluorescent probes. By simultaneously optimizing these design criteria, we created a new generation of near-infrared fluorescent core-shell silica-based nanoparticles (C dots) tuned to hydrodynamic diameters of 3.3 and 6.0 nm with improved photophysical characteristics over the parent dye. A neutral organic coating prevented adsorption of serum proteins and facilitated efficient urinary excretion. Detailed particle biodistribution studies were performed using more quantitative ex vivo fluorescence detection protocols and combined optical-PET imaging. The results suggest that this new generation of C dots constitutes a promising clinically translatable materials platform which may be adapted for tumor targeting and treatment. © 2009 American Chemical Society. |
| Keywords: | treatment response; methodology; mouse; animal; animals; mice; fluorescence; chemistry; tumor targeting; tissue distribution; whole body imaging; tumors; organ specificity; adsorption; biocompatibility; fluid dynamics; medical nanotechnology; nanoparticles; organic coatings; probes; silica; bio distributions; biological barriers; biostability; clinical translations; design criterion; ex-vivo; fluorescent cores; fluorescent probes; fluorescent silica nanoparticles; high sensitivities; hydrodynamic diameters; in-vivo; nanomedicine; near infra reds; pet imaging; photophysical; quantitative imaging; serum proteins; tumor detections; urinary excretions; contrast medium; nanoparticle; silicon dioxide; antibody specificity; fluorescence microscopy; metabolic clearance rate; urine; contrast media; microscopy, fluorescence |
| Journal Title: | Nano Letters |
| Volume: | 9 |
| Issue: | 1 |
| ISSN: | 1530-6984 |
| Publisher: | American Chemical Society |
| Date Published: | 2009-01-01 |
| Start Page: | 442 |
| End Page: | 448 |
| Language: | English |
| DOI: | 10.1021/nl803405h |
| PUBMED: | 19099455 |
| PROVIDER: | scopus |
| PMCID: | PMC6262890 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 25" - "Export Date: 30 November 2010" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work