Cognition in patients treated with targeted therapy for chronic myeloid leukemia: A controlled comparison Journal Article
| Authors: | Hyland, K. A.; Eisel, S. L.; Hoogland, A. I.; Root, J. C.; Bowles, K.; James, B.; Nelson, A. M.; Booth-Jones, M.; Jacobsen, P. B.; Ahles, T. A.; Jim, H. S. L.; Gonzalez, B. D. |
| Article Title: | Cognition in patients treated with targeted therapy for chronic myeloid leukemia: A controlled comparison |
| Abstract: | This controlled comparison study evaluated objective and subjective cognitive function and their relationships with patient-reported symptoms (depression, fatigue, insomnia) in patients receiving tyrosine kinase inhibitors (TKIs) for chronic myeloid leukemia (CML) and non-cancer controls. Patients with CML in chronic phase treated with the same oral TKI for ≥6 months (n = 90) and non-cancer controls (n = 87) completed a neurocognitive battery and self-report measures. Patients demonstrated worse overall neuropsychological performance (p =.05) and verbal memory (p =.02) compared to controls. Patients were not more likely to meet criteria for impaired cognitive performance compared to controls (ps>.26). Patients reported worse subjective global and domain-specific cognitive complaints and less satisfaction with cognitive function compared to controls (ps <.05). Patients also reported greater fatigue and insomnia symptoms (ps <.001). In both groups, greater fatigue, insomnia, and depressive symptoms were associated with worse subjective cognition (ps <.01). Longitudinal studies are needed to examine changes in cognitive function in patients before and during TKI treatment. © 2022 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | fatigue; protein kinase inhibitor; chronic myeloid leukemia; protein kinase inhibitors; insomnia; cognition; leukemia, myelogenous, chronic, bcr-abl positive; complication; sleep initiation and maintenance disorders; humans; human |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 64 |
| Issue: | 2 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2023-01-01 |
| Start Page: | 415 |
| End Page: | 423 |
| Language: | English |
| DOI: | 10.1080/10428194.2022.2148208 |
| PUBMED: | 36476293 |
| PROVIDER: | scopus |
| PMCID: | PMC10305842 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2023 -- Source: Scopus |
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