Markerless motion tracking with simultaneous MV and kV imaging in spine SBRT treatment—A feasibility study Journal Article


Authors: Cai, W.; Fan, Q.; Li, F.; He, X.; Zhang, P.; Cervino, L.; Li, X.; Li, T.
Article Title: Markerless motion tracking with simultaneous MV and kV imaging in spine SBRT treatment—A feasibility study
Abstract: Objective. Motion tracking with simultaneous MV-kV imaging has distinct advantages over single kV systems. This research is a feasibility study of utilizing this technique for spine stereotactic body radiotherapy (SBRT) through phantom and patient studies. Approach. A clinical spine SBRT plan was developed using 6xFFF beams and nine sliding-window IMRT fields. The plan was delivered to a chest phantom on a linear accelerator. Simultaneous MV-kV image pairs were acquired during beam delivery. KV images were triggered at predefined intervals, and synthetic MV images showing enlarged MLC apertures were created by combining multiple raw MV frames with corrections for scattering and intensity variation. Digitally reconstructed radiograph (DRR) templates were generated using high-resolution CBCT reconstructions (isotropic voxel size (0.243 mm)3) as the reference for 2D-2D matching. 3D shifts were calculated from triangulation of kV-to-DRR and MV-to-DRR registrations. To evaluate tracking accuracy, detected shifts were compared to known phantom shifts as introduced before treatment. The patient study included a T-spine patient and an L-spine patient. Patient datasets were retrospectively analyzed to demonstrate the performance in clinical settings. Main results. The treatment plan was delivered to the phantom in five scenarios: no shift, 2 mm shift in one of the longitudinal, lateral and vertical directions, and 2 mm shift in all the three directions. The calculated 3D shifts agreed well with the actual couch shifts, and overall, the uncertainty of 3D detection is estimated to be 0.3 mm. The patient study revealed that with clinical patient image quality, the calculated 3D motion agreed with the post-treatment cone beam CT. It is feasible to automate both kV-to-DRR and MV-to-DRR registrations using a mutual information-based method, and the difference from manual registration is generally less than 0.3 mm. Significance. The MV-kV imaging-based markerless motion tracking technique was validated through a feasibility study. It is a step forward toward effective motion tracking and accurate delivery for spinal SBRT. © 2023 Institute of Physics and Engineering in Medicine.
Keywords: retrospective studies; retrospective study; feasibility study; computerized tomography; feasibility studies; radiosurgery; stereotactic body radiotherapy; radiotherapy planning, computer-assisted; phantoms, imaging; patient treatment; motion; phantoms; spine stereotactic body radiotherapy; procedures; uncertainty analysis; radiotherapy treatment; imaging phantom; humans; human; radiotherapy planning system; motion analysis; digitally reconstructed radiographs; spine sbrt; motion tracking; mv-kv; phantom study; markerless motion; phantom studies
Journal Title: Physics in Medicine and Biology
Volume: 68
Issue: 3
ISSN: 0031-9155
Publisher: IOP Publishing Ltd  
Date Published: 2023-02-07
Start Page: 035012
Language: English
DOI: 10.1088/1361-6560/acae16
PUBMED: 36549010
PROVIDER: scopus
PMCID: PMC9944511
DOI/URL:
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PubMed record and PDF. Corresponding author is MSK author Tianfang Li -- Export Date: 1 March 2023 -- Source: Scopus
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MSK Authors
  1. Pengpeng Zhang
    175 Zhang
  2. Xiang   Li
    70 Li
  3. Tianfang Li
    48 Li
  4. Weixing Cai
    32 Cai
  5. Qiyong Fan
    19 Fan
  6. Feifei Li
    18 Li
  7. Xiuxiu He
    18 He