Current evidence-based systemic therapy for advanced and recurrent endometrial cancer Review

  


Authors: Gordhandas, S.; Zammarrelli, W. A. 3rd; Rios-Doria, E. V.; Green, A. K.; Makker, V.
Review Title: Current evidence-based systemic therapy for advanced and recurrent endometrial cancer
Abstract: Endometrial cancer (EC) is the most common gynecologic malignancy, with worldwide increasing incidence and disease-associated mortality. Although most patients with EC are diagnosed with early-stage disease, systemic treatment options for patients with advanced or recurrent EC have historically been limited. EC-focused clinical trials and the ensuing therapeutic landscape have expanded since The Cancer Genome Atlas (TCGA) identified 4 distinct EC subgroups associated with differential survival. This endeavor revolutionized our understanding of the genomic characterization of EC as well as molecular drivers of this heterogeneous malignancy, leading to precision oncology approaches to therapeutics and advancement in treatment options. This review describes the current status of and recent advancements in therapeutic options for patients with advanced and recurrent EC. The NCCN Guidelines for Uterine Neoplasms provide detailed recommendations regarding the diagnosis, workup, and management of EC.
Keywords: genetics; systemic therapy; endometrial neoplasms; neoplasm recurrence, local; genital neoplasms, female; immunotherapy; tumor recurrence; targeted therapy; uterus cancer; uterine neoplasms; endometrium tumor; female genital tract tumor; personalized medicine; recurrent endometrial cancer; advanced endometrial cancer; humans; human; female; precision medicine
Journal Title: Journal of the National Comprehensive Cancer Network
Volume: 21
Issue: 2
ISSN: 1540-1405
Publisher: Harborside Press  
Date Published: 2023-02-01
Start Page: 217
End Page: 226
Language: English
DOI: 10.6004/jnccn.2022.7254
PUBMED: 36791759
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85148115135&doi=10.6004%2fjnccn.2022.7254&partnerID=40&md5=fba4ceca232a0afa89db04f3e5d11a95
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF -- Corresponding author is MSK authors: Vicky Makker -- Source: Scopus
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MSK Authors
  1. Vicky Makker
    263 Makker
  2. Angela Kellen Green
    40 Green
  3. Eric Vincent Rios-Doria
    35 Rios-Doria
  4. William Anthony Zammarrelli
    24 Zammarrelli
  5. Sushmita Bharat Gordhandas
    47 Gordhandas
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