Radiologic and histopathologic features of hydrogel sealant after lung resection in participants of a prospective randomized clinical trial Journal Article
| Authors: | Moussa, A. M.; Hui, Y.; Araujo Filho, J. A.; Muallem, N.; Li, D.; Jihad, M.; Hsu, M.; Moskowitz, C. S.; Travis, W. D.; Solomon, S. B.; Ginsberg, M. S.; Maybody, M. |
| Article Title: | Radiologic and histopathologic features of hydrogel sealant after lung resection in participants of a prospective randomized clinical trial |
| Abstract: | Purpose: To summarize imaging and histopathologic characteristics of hydrogel sealant (plug) in lung parenchyma and assess their correlation with time since deployment of sealant. Materials and methods: Among a total of 208 participants randomized to the hydrogel sealant arm of a lung biopsy prospective randomized clinical trial, 51 underwent resection of the biopsied lesion. In 34 participants sealant material was present on histopathologic sections (n = 22), or they had cross-sectional imaging of chest between biopsy and resection (n = 23) or they had both imaging and histopathology (n = 11). Histopathologic and imaging findings were described. The association of these findings with time since sealant deployment was evaluated using the Wilcoxon rank sum test. Results: The mean time since sealant deployment for histopathology was 45.7 days (median 36, range 14–181) and for imaging studies was 99 days (median 32, range 4–527). The sealant was infiltrated by inflammatory cells in 20 (91%) participants. The main general histopathologic pattern of sealant was foamy in 12 (57%) and mesh in 8 (38%) participants. Imaging appearance of sealant was serpiginous in 18 (60%), linear in 10 (33%) or lobulated in 2 (6.7%) participants. In 2 participants the sealant was hypermetabolic with no histopathologic evidence of tumor. No correlation was found between time since sealant deployment and imaging or histopathologic appearances. Conclusion: Hydrogel sealant appears as a serpiginous, linear, or lobulated opacity on cross-sectional imaging which can be metabolically active. It is associated with an inflammatory reaction with a foamy or mesh general pattern on histopathological assessment. No correlation was found between time since sealant deployment and imaging or histopathologic appearances. © 2022 Elsevier Inc. |
| Keywords: | controlled study; prospective study; prospective studies; randomized controlled trial; lung neoplasms; tomography, x-ray computed; pathology; diagnostic imaging; biopsy; lung tumor; computerized tomography; pneumothorax; lung; drug therapy; lung biopsy; biological organs; randomized clinical trials; procedures; hydrogel; hydrogels; humans; human; cross-sectional imaging; x-ray computed tomography; prospectives; mesh generation; ct guided lung biopsy; hydrogel sealant; plug; tract sealant; sealants; plug-ins |
| Journal Title: | Clinical Imaging |
| Volume: | 95 |
| ISSN: | 0899-7071 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2023-03-01 |
| Start Page: | 92 |
| End Page: | 96 |
| Language: | English |
| DOI: | 10.1016/j.clinimag.2022.12.008 |
| PUBMED: | 36706641 |
| PROVIDER: | scopus |
| PMCID: | PMC10041988 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in the PDF -- MSK corresponding author is Amgad Moussa -- Export Date: 1 March 2023 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
Related MSK Work