Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia Journal Article
| Authors: | Pereira-Martins, D. A.; Coelho-Silva, J. L.; Weinhäuser, I.; Franca-Neto, P. L.; Silveira, D. R.; Ortiz, C.; Moreira-Aguiar, A.; Lima, M. M.; Koury, L. C.; de Melo, R. A.; Glória, A. B.; Fagundes, E.; Lino, B. K.; Pagnano, K.; Bittencourt, R.; Nunes, E.; Traina, F.; Figueiredo-Pontes, L.; Keating, A.; Tallman, M. S.; Ribeiro, R. C.; Dilon, R.; Ganser, A.; Sanz, M. A.; Berliner, N.; Valk, P.; Löwenberg, B.; Ottone, T.; Noguera, N. I.; Voso, M. T.; Paoloni, F.; Fazi, P.; Ammatuna, E.; Huls, G.; Schuringa, J.; Rego, E. M.; Lucena-Araujo, A. R. |
| Article Title: | Clinical significance of mitochondrial DNA content in acute promyelocytic leukaemia |
| Abstract: | Although a growing body of evidence demonstrates that altered mtDNA content (mtDNAc) has clinical implications in several types of solid tumours, its prognostic relevance in acute promyelocytic leukaemia (APL) patients remains largely unknown. Here, we show that patients with higher-than-normal mtDNAc had better outcomes regardless of tumour burden. These results were more evident in patients with low-risk of relapse. The multivariate Cox proportional hazard model demonstrated that high mtDNAc was independently associated with a decreased cumulative incidence of relapse. Altogether, our data highlights the possible role of mitochondrial metabolism in APL patients treated with ATRA. © 2022 British Society for Haematology and John Wiley & Sons Ltd. |
| Keywords: | controlled study; treatment outcome; human cell; major clinical study; genetics; cancer recurrence; cancer patient; disease free survival; antineoplastic agent; gene; disease association; neoplasm recurrence, local; tumor volume; antineoplastic combined chemotherapy protocols; cohort analysis; evidence based practice; gene function; leukemia, promyelocytic, acute; proportional hazards model; tumor recurrence; promyelocytic leukemia; real time polymerase chain reaction; bone marrow cell; anthracycline; dna, mitochondrial; retinoic acid; oxidative phosphorylation; mitochondrial dna; log rank test; cumulative incidence; mitochondrial respiration; clinical outcome; tretinoin; atra; low risk patient; dna content; cancer prognosis; clinical relevance; humans; human; article; anthracycline-based chemotherapy; mtdna content; hbb gene; pklr gene |
| Journal Title: | British Journal of Haematology |
| Volume: | 200 |
| Issue: | 2 |
| ISSN: | 0007-1048 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2023-01-01 |
| Start Page: | 170 |
| End Page: | 174 |
| Language: | English |
| DOI: | 10.1111/bjh.18510 |
| PUBMED: | 36263593 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2023 -- Source: Scopus |
