Fat-containing adnexal masses on MRI: Solid tissue volume and fat distribution as a guide for O-RADS Score assignment Journal Article
| Authors: | Cheng, M.; Causa Andrieu, P.; Kim, T. H.; Gangai, N.; Sonoda, Y.; Hricak, H.; Lakhman, Y.; Vargas, H. A.; Woo, S. |
| Article Title: | Fat-containing adnexal masses on MRI: Solid tissue volume and fat distribution as a guide for O-RADS Score assignment |
| Abstract: | Purpose: To explore ways to improve O-RADS MRI scoring for fat-containing adnexal masses, by investigating methods for quantifying solid tissue volume and fat distribution and evaluating their associations with malignancy. Methods: This retrospective, single-center study included patients with fat-containing adnexal masses on MRI during 2008–2021. Two radiologists independently reviewed overall size (Sizeoverall), size of any solid tissue (Sizeanysolid), size of solid tissue that was not Rokitansky nodule (Sizenon-Rokitansky), and fat distribution. Wilcoxon test, Fisher-exact test, and ROC curve analysis were performed. Reference standard was pathology or follow-up > 24 months. Results: 188 women (median age 35 years) with 163 benign and 25 malignant lesions were included. Sizeoverall (R1, 9.9 cm vs 5.9 cm; R2, 12.4 cm vs 6.0 cm), Sizeanysolid (R1, 5.1 cm vs 1.2 cm; R2, 3.2 cm vs 0.0 cm), Sizenon-Rokitansky (R1, 5.1 cm vs 0.0 cm; R2, 3.1 cm vs 0.0 cm), and fat distribution differed significantly between malignant and benign lesions (p < 0.01). Area under ROC curve was greatest using Sizenon-Rokitansky (R1, 0.83; R2, 0.86) vs Sizeoverall (R1, 0.78; R2, 0.81) or Sizeanysolid (R1, 0.79; R2, 0.81), though differences were non-significant (p = 0.48–0.93). Cutoffs for Sizenon-Rokitansky (R1, ≥ 1.2 cm; R2, ≥ 1.0 cm) yielded sensitivity and specificity of 0.72 and 0.93 (R1) and 0.76 and 0.95 (R2). Among immature teratomas, 85.7% displayed scattered fat. Conclusion: Overall size, size of (any or non-Rokitansky-nodule) solid tissue, and fat distribution differed between benign and malignant fat-containing adnexal masses. Incorporating these would constitute simple and practical approaches to refining O-RADS MRI scoring. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature. |
| Keywords: | magnetic resonance imaging; ovary; teratoma; fat; o-rads |
| Journal Title: | Abdominal Radiology |
| Volume: | 48 |
| Issue: | 1 |
| ISSN: | 2366-004X |
| Publisher: | Springer |
| Date Published: | 2023-01-01 |
| Start Page: | 358 |
| End Page: | 366 |
| Language: | English |
| DOI: | 10.1007/s00261-022-03688-x |
| PUBMED: | 36173552 |
| PROVIDER: | scopus |
| PMCID: | PMC11149608 |
| DOI/URL: | |
| Notes: | Article -- MSK Cancer Center Support Grant (P30 CA008748) acknowledged in PubMed record and PDF -- MSK corresponding author is Sungming Woo -- Export Date: 1 February 2023 -- Source: Scopus |
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