Precision oncology using organoids of a secretory carcinoma of the salivary gland treated with TRK-inhibitors Journal Article
| Authors: | Lassche, G.; van Engen - van Grunsven, A. C. H.; van Hooij, O.; Aalders, T. W.; Weijers, J. A. M.; Cocco, E.; Drilon, A.; Hoischen, A.; Neveling, K.; Schalken, J. A.; Verhaegh, G. W.; van Herpen, C. M. L. |
| Article Title: | Precision oncology using organoids of a secretory carcinoma of the salivary gland treated with TRK-inhibitors |
| Abstract: | The use of anticancer drugs targeting specific molecular tumor characteristics is rapidly increasing in clinical practice, but selecting patients to benefit from these remains a challenge. It has been suggested that organoid cultures would be ideally suited to test drug responses in vitro. Here we describe and characterize in depth a case of ETV6-NTRK3 gene fusion-positive secretory carcinoma of the salivary glands and corresponding organoid cultures that responded and subsequently acquired resistance to TRK targeting therapy with larotrectinib. This case-culture-characterization illustrates the advances made in precision oncology, but also exposes important caveats in using organoids to predict treatment response. © 2022 The Author(s) |
| Keywords: | adult; clinical article; human tissue; treatment response; middle aged; case report; cancer radiotherapy; liver toxicity; gene fusion; brain metastasis; corticosteroid; salivary gland carcinoma; skin metastasis; personalized medicine; medical history; parotidectomy; human; male; article; organoid; ntrk3 gene; larotrectinib; etv6 gene; ntrk3 receptor [mesh]; organoids [mesh]; precision medicine [mesh]; salivary gland neoplasms [mesh] |
| Journal Title: | Oral Oncology |
| Volume: | 137 |
| ISSN: | 1368-8375 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2023-02-01 |
| Start Page: | 106297 |
| Language: | English |
| DOI: | 10.1016/j.oraloncology.2022.106297 |
| PUBMED: | 36610231 |
| PROVIDER: | scopus |
| PMCID: | PMC10360362 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 February 2023 -- Source: Scopus |
