New readers and writers of RNA modifications unique to leukemia stem cells Editorial

  


Authors: Fujino, T.; Abdel-Wahab, O.
Title: New readers and writers of RNA modifications unique to leukemia stem cells
Abstract: Chemical modifications of RNA are regulated by a series of readers, writers, and erasers that dictate gene expression. Two new studies in Cell Stem Cell1,2 identify roles for the N6-methyladenosine (m6A) methyltransferase METTL16 and the m6A reader IGF2BP2 in leukemia-initiating cells, illuminating exciting new therapeutic targets for leukemia. © 2022 Elsevier Inc.
Keywords: leukemia; methylation; genetics; nonhuman; note; metabolism; cell population; stem cell; rna binding protein; rna; rna-binding proteins; methyltransferase; methyltransferases; messenger rna; immunoprecipitation; stem cells; hematopoietic stem cell; malignant transformation; nucleotide; chemical modification; docosahexaenoic acid; acute myeloid leukemia; humans; human; igf2bp2 protein, human; mettl16 protein, human
Journal Title: Cell Stem Cell
Volume: 30
Issue: 1
ISSN: 1934-5909
Publisher: Cell Press  
Date Published: 2023-01-05
Start Page: 3
End Page: 4
Language: English
DOI: 10.1016/j.stem.2022.12.011
PUBMED: 36608677
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145182534&doi=10.1016%2fj.stem.2022.12.011&partnerID=40&md5=84ce14d96dc5223b3daaa145dd4a8d1d
Notes: Note -- Export Date: 1 February 2023 -- Source: Scopus
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MSK Authors
  1. Omar Ibrahim Abdel-Wahab
    573 Abdel-Wahab
  2. Takeshi Fujino
    5 Fujino
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