A framework for evaluating the technical performance of multiparameter quantitative imaging biomarkers (mp-QIBs) Review
| Authors: | Obuchowski, N. A.; Huang, E.; deSouza, N. M.; Raunig, D.; Delfino, J.; Buckler, A.; Hatt, C.; Wang, X.; Moskowitz, C.; Guimaraes, A.; Giger, M.; Hall, T. J.; Kinahan, P.; Pennello, G. |
| Review Title: | A framework for evaluating the technical performance of multiparameter quantitative imaging biomarkers (mp-QIBs) |
| Abstract: | Multiparameter quantitative imaging incorporates anatomical, functional, and/or behavioral biomarkers to characterize tissue, detect disease, identify phenotypes, define longitudinal change, or predict outcome. Multiple imaging parameters are sometimes considered separately but ideally are evaluated collectively. Often, they are transformed as Likert interpretations, ignoring the correlations of quantitative properties that may result in better reproducibility or outcome prediction. In this paper we present three use cases of multiparameter quantitative imaging: i) multidimensional descriptor, ii) phenotype classification, and iii) risk prediction. A fourth application based on data-driven markers from radiomics is also presented. We describe the technical performance characteristics and their metrics common to all use cases, and provide a structure for the development, estimation, and testing of multiparameter quantitative imaging. This paper serves as an overview for a series of individual articles on the four applications, providing the statistical framework for multiparameter imaging applications in medicine. © 2022 The Association of University Radiologists |
| Keywords: | treatment response; review; nuclear magnetic resonance imaging; clinical practice; reproducibility; biomarkers; biological marker; reproducibility of results; phenotype; computer assisted tomography; image analysis; calibration; developmental biology; diagnostic imaging; correlation analysis; quantitative analysis; clinical evaluation; behavior; conceptual framework; software; genetic predisposition; statistical model; atherosclerotic plaque; tissue structure; clinical medicine; gastrointestinal tumor; uncertainty; clinical outcome; radiological parameters; procedures; risk prediction; human; physiological process; technical performance; measurement repeatability; radiomics; multiparametric imaging; quantitative imaging biomarkers; phenotype classification; qiba; performance indicator; multidimensional descriptor; multiparameter quantitative imaging |
| Journal Title: | Academic Radiology |
| Volume: | 30 |
| Issue: | 2 |
| ISSN: | 1076-6332 |
| Publisher: | Elsevier Science, Inc. |
| Date Published: | 2023-02-01 |
| Start Page: | 147 |
| End Page: | 158 |
| Language: | English |
| DOI: | 10.1016/j.acra.2022.08.031 |
| PUBMED: | 36180328 |
| PROVIDER: | scopus |
| PMCID: | PMC9825639 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 February 2023 -- Source: Scopus |
