American Head and Neck Society position statement on the use of PD-1 inhibitors for treatment of advanced cutaneous squamous cell carcinoma Guidelines
| Authors: | Schmalbach, C. E.; Ow, T. J.; Choi, K. Y.; O'Leary, M.; Lin, A.; Hughley, B. B.; Emerick, K. S.; Moore, B.; Lee, N. Y.; Zandberg, D. P.; Wang, S. J. |
| Title: | American Head and Neck Society position statement on the use of PD-1 inhibitors for treatment of advanced cutaneous squamous cell carcinoma |
| Abstract: | Background: A position statement put forth by the American Head and Neck Society (AHNS) was constructed to provide evidence-based treatment recommendations for PD-1 inhibitor use in advanced cutaneous squamous cell carcinoma (cSCC). Secondarily, we sought to identify knowledge gaps warranting further investigation. Methods: A literature search utilizing key terms: cutaneous squamous cell carcinoma, cutaneous cancer, checkpoint inhibitors, systemic therapy, Program Cell Death, PD-1 (PubMed, Cochrane, and Google Scholar) was carried out to generate evidence-based statements. The statements were distributed among the AHNS membership. Delphi methodology was applied to identify statements achieving 70% or greater consensus among the leadership team. Results: Twenty-six position statements achieved consensus. Knowledge gaps for future research included: impact of immunosuppression on cSCC staging and associated treatment; role of PD-1 inhibitors in immunosuppressed patients. Conclusion: This comprehensive position statement put forth by the AHNS represents majority consensus by practicing head and neck surgeons throughout the country. © 2022 Wiley Periodicals LLC. |
| Keywords: | cancer surgery; unclassified drug; squamous cell carcinoma; carcinoma, squamous cell; advanced cancer; systemic therapy; drug approval; united states; cancer patient; cancer radiotherapy; cancer staging; sentinel lymph node biopsy; evidence-based medicine; cancer immunotherapy; consensus; skin neoplasms; evidence based practice; tumor biopsy; food and drug administration; pathology; oncology; skin tumor; head and neck neoplasms; carcinoma; medical society; medline; delphi study; cochrane library; head and neck tumor; conflict of interest; clinical trial (topic); clinical outcome; squamous cell; epidermoid carcinoma; immune checkpoint inhibitor; humans; human; article; immune checkpoint inhibitors; immunological antineoplastic agent; squamous cell skin carcinoma; pd 1 inhibitor |
| Journal Title: | Head & Neck |
| Volume: | 45 |
| Issue: | 1 |
| ISSN: | 1043-3074 |
| Publisher: | John Wiley & Sons, Inc. |
| Date Published: | 2023-01-01 |
| Start Page: | 32 |
| End Page: | 41 |
| Language: | English |
| DOI: | 10.1002/hed.27202 |
| PUBMED: | 36181317 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 January 2023 -- Source: Scopus |
