Analyzing the spatial randomness in the distribution of acquired melanocytic neoplasms Journal Article

Authors: Chousakos, E.; Kose, K.; Kurtansky, N. R.; Dusza, S. W.; Halpern, A. C.; Marghoob, A. A.
Article Title: Analyzing the spatial randomness in the distribution of acquired melanocytic neoplasms
Abstract: On the basis of the clinical impression and current knowledge, acquired melanocytic nevi and melanomas may not occur in random localizations. The goal of this study was to identify whether their distribution on the back is random and whether the location of melanoma correlates with its adjacent lesions. Therefore, patient-level and lesion-level spatial analyses were performed using the Clark‒Evans test for complete spatial randomness. A total of 311 patients with three-dimensional total body photography (average age of 40.08 [30‒49] years; male/female ratio: 128/183) with 5,108 eligible lesions in total were included in the study (mean sum of eligible lesions per patient of 16.42 [3‒199]). The patient-level analysis revealed that the distributions of acquired melanocytic neoplasms were more likely to deviate toward clustering than dispersion (average z-score of ‒0.55 [95% confidence interval = ‒0.69 to ‒0.41; P < 0.001]). The lesion-level analysis indicated a higher portion of melanomas (n = 57 of 72, 79.2% [95% confidence interval = 69.4‒88.9%]) appearing in proximity to neighboring melanocytic neoplasms than to nevi (n = 2,281 of 5,036, 45.3% [95% confidence interval = 43.9‒46.7%]). In conclusion, the nevi and melanomas’ distribution on the back tends toward clustering as opposed to dispersion. Furthermore, melanomas are more likely to appear proximally to their neighboring neoplasms than to nevi. These findings may justify various oncogenic theories and improve diagnostic methodology. © 2022 The Authors
Keywords: adult; major clinical study; disease classification; melanoma; nevus; skin neoplasms; prevalence; pathology; retrospective study; high risk patient; confidence interval; skin tumor; nevus, pigmented; back; medical photography; photography; spatial analysis; demographics; pigmented nevus; body distribution; three-dimensional imaging; humans; human; male; female; article; acquired melanocytic nevus; clark evans score; data clustering
Journal Title: Journal of Investigative Dermatology
Volume: 142
Issue: 12
ISSN: 0022-202X
Publisher: Elsevier Science, Inc.  
Date Published: 2022-12-01
Start Page: 3274
End Page: 3281
Language: English
DOI: 10.1016/j.jid.2022.06.011
PUBMED: 35841946
PROVIDER: scopus
PMCID: PMC10475172
Notes: Article -- Export Date: 3 January 2023 -- Source: Scopus
Citation Impact
MSK Authors
  1. Allan C Halpern
    385 Halpern
  2. Stephen Dusza
    255 Dusza
  3. Ashfaq A Marghoob
    507 Marghoob
  4. Kivanc Kose
    72 Kose
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