Molecular genetics of bone tumors Review
| Author: | Agaram, N. P. |
| Review Title: | Molecular genetics of bone tumors |
| Abstract: | Bone tumours comprise a heterogenous group of benign and malignant neoplasms primarily involving the bone. They are currently classified based on the type of matrix deposited into cartilaginous tumours, bone forming tumours, fibrous tumors, giant-cell rich tumours, etc. Although histomorphology has been the basis of diagnosis of bone tumours for a long time, recent studies using advanced molecular methodologies has brought about an increased understanding of tumours and has helped in the development of diagnostic markers for some tumours. In this review, the molecular genetics of the most common bone tumours are discussed; with an emphasis on the usage of some of the diagnostic markers in everyday practice of bone pathology. © 2022 |
| Keywords: | immunohistochemistry; osteosarcoma; bone tumor; gene mutation; human cell; mutation; review; molecular genetics; cancer grading; gene amplification; angiosarcoma; carcinogenesis; fluorescence in situ hybridization; chondrosarcoma; chordoma; chromosome 12q; cytogenetic analysis; mdm2; osteochondroma; idh; isocitrate dehydrogenase 1; enchondroma; chondroblastoma; osteoblastoma; chondromatosis; aneurysmal bone cyst; fibrous dysplasia; mesenchymal chondrosarcoma; osteoid osteoma; epithelioid hemangioendothelioma; cartilage tumor; parosteal osteosarcoma; high throughput sequencing; isocitrate dehydrogenase 2; ameloblastoma; transcription factor fosb; osteoclastoma; periosteal chondroma; human; oncogene c fos; epithelioid hemangioma; h3k36m; h3g34w; bone ameloblastoma; bone epithelioid hemangioendothelioma; bone epithelioid hemangioma; chondromyxoid fibroma; low grade central osteosarcoma |
| Journal Title: | Diagnostic Histopathology |
| Volume: | 28 |
| Issue: | 12 |
| ISSN: | 1756-2317 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-12-01 |
| Start Page: | 541 |
| End Page: | 551 |
| Language: | English |
| DOI: | 10.1016/j.mpdhp.2022.09.004 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 January 2023 -- Source: Scopus |
