Synapse - Clinical features of young onset colorectal cancer patients from a large cohort at a single cancer center

Clinical features of young onset colorectal cancer patients from a large cohort at a single cancer center Journal Article

Authors:	Park, L.; O’Connell, K.; Herzog, K.; Chatila, W.; Walch, H.; Palmaira, R. L. D.; Cercek, A.; Shia, J.; Shike, M.; Markowitz, A. J.; Garcia-Aguilar, J.; Schattner, M. A.; Kantor, E. D.; Du, M.; Mendelsohn, R. B.
Article Title:	Clinical features of young onset colorectal cancer patients from a large cohort at a single cancer center
Abstract:	Purpose: The aim of this study is to describe the demographics and clinical features of patients with young onset (YO) CRC. Methods: A retrospective review of patients with CRC diagnosed between ages 20 and 49 years was evaluated at the Memorial Sloan Kettering Cancer Center from 1/2004 to 6/2019. We excluded those with a hereditary CRC syndrome, inflammatory bowel disease, or prior CRC diagnosis. Patient demographics; presenting symptoms; medical, surgical, and smoking history; family history of cancer; tumor characteristics; and pathology were obtained from the electronic medical record. Results: We identified 3856 YO CRC patients (median age CRC diagnosis 43; 52.5% male). A total of 59.1% were overweight or obese (32.2% and 26.9%, respectively). Most (90.1%) had no family history of CRC in a first-degree relative; 56.3% of patients reported being never smokers; 5.2% had diabetes. The most common presenting symptoms were rectal bleeding (47.7%), abdominal pain/bloating (33.1%), and change in bowel habits (24.7%). The majority presented with left-sided cancers (77.3%), at late-stage disease (68.4% at stages 3 or 4). Conclusion: Most YO CRC patients presented with rectal bleeding or abdominal pain, left-sided cancers, and later-stage disease and had no family history of CRC in a first-degree relative. Over half were overweight and obese and were more likely to have never smoked. More data are needed to better understand YO CRC risk factors and to help identify high-risk populations who may benefit from earlier screening. © 2022, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Keywords:	adult; controlled study; middle aged; retrospective studies; young adult; major clinical study; genetics; clinical feature; cancer risk; gastrointestinal hemorrhage; cancer patient; cancer staging; cancer diagnosis; colorectal cancer; cohort analysis; obesity; cancer screening; smoking; pathology; retrospective study; abdominal pain; colorectal neoplasms; cancer center; electronic medical record; colorectal tumor; family history; diabetes mellitus; onset age; colorectal cancer screening; rectum; rectum hemorrhage; defecation habit; bloating; complication; demographics; defecation; non-smoker; first-degree relative; humans; human; male; female; article; patient history of surgery; early-onset colorectal cancer; young-onset colorectal cancer
Journal Title:	International Journal of Colorectal Disease
Volume:	37
Issue:	12
ISSN:	0179-1958
Publisher:	Springer
Date Published:	2022-12-01
Start Page:	2511
End Page:	2516
Language:	English
DOI:	10.1007/s00384-022-04286-5
PUBMED:	36441197
PROVIDER:	scopus
PMCID:	PMC10007691
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142905442&doi=10.1007%2fs00384-022-04286-5&partnerID=40&md5=7a188c56f04424173b08c83e4eefc949
Notes:	Article -- The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in the PDF. Corresponding author is MSK author Robin B. Mendelsohn. -- Export Date: 3 January 2023 -- Source: Scopus