Irinotecan dose schedule for the treatment of Ewing sarcoma Review
| Authors: | Slotkin, E. K.; Meyers, P. A. |
| Review Title: | Irinotecan dose schedule for the treatment of Ewing sarcoma |
| Abstract: | Irinotecan and temozolmide achieve objective responses in patients with Ewing sarcoma that recurs after initial therapy. Optimal dose schedules have not been defined. We reviewed published series of patients treated with irinotecan and temozolomide for Ewing sarcoma that recurred after initial therapy. We compared objective response rates for patients who received 5-day irinotecan treatment schedules to response rates for patients who achieved 10-day irinotecan treatment schedules. Among 89 patients treated with a 10-day irinotecan schedule, there were 47 objective responses (53%). Among 180 patients treated with a 5-day irinotecan schedule, there were 52 responses (29%). In the treatment of recurrent Ewing sarcoma, investigators should consider the use of a 10-day schedule for administration of irinotecan. |
| Keywords: | topotecan; vincristine; irinotecan; ewing sarcoma; children; trial; phase-i; combination; refractory solid tumors; pediatric-patients; oral irinotecan; dose schedule; temozolomide voit |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 70 |
| Issue: | 1 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2023-01-01 |
| Start Page: | e30005 |
| Language: | English |
| ACCESSION: | WOS:000863970200001 |
| DOI: | 10.1002/pbc.30005 |
| PROVIDER: | wos |
| PUBMED: | 36184748 |
| Notes: | Article -- Corresponding author is MSK author Paul A. Meyers -- Source: Wos |
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