Prognostic impact of autoimmune disease in oral cavity squamous cell carcinoma Journal Article
| Authors: | Pillai, A.; Valero, C.; Zanoni, D.; Navas, K.; Morris, Q.; Ganly, I.; Patel, S. G. |
| Article Title: | Prognostic impact of autoimmune disease in oral cavity squamous cell carcinoma |
| Abstract: | Background and Objectives: Recent literature has highlighted the role of the host in the prognosis of oral squamous cell carcinoma (OSCC). In this study, we retrospectively examined the impact of autoimmune (AI) disorders as an aspect of the host status on survival outcomes in OSCC patients. Methods: From a departmental database of OSCC patients (n = 1369), 123 patients with an AI disorder were identified. AI and no-AI groups were compared for survival outcomes. Results: There were no significant differences in survival between groups for overall survival, disease-specific survival, local, regional, and distant recurrence-free probabilities. However, survival and recurrence-free probabilities were poorer in the AI group versus the no AI group. Conclusion: Patients with AI disease trended towards worse outcomes. This suggests immune dysregulation in these patients may impact oncologic outcomes. © 2022 Wiley Periodicals LLC. |
| Keywords: | adult; cancer survival; controlled study; aged; cancer surgery; survival rate; retrospective studies; major clinical study; overall survival; squamous cell carcinoma; carcinoma, squamous cell; cancer patient; outcome assessment; antineoplastic agent; cohort analysis; pathology; data base; retrospective study; psoriasis; head and neck cancer; head and neck neoplasms; diabetes mellitus; idiopathic thrombocytopenic purpura; rheumatoid arthritis; systemic lupus erythematosus; ulcerative colitis; autoimmune diseases; autoimmune disease; multiple sclerosis; adjuvant radiotherapy; sarcoidosis; disease specific survival; mouth neoplasms; head and neck tumor; crohn disease; mouth cavity; recurrence free survival; complication; mouth squamous cell carcinoma; primary biliary cirrhosis; mouth tumor; demographics; hashimoto disease; celiac disease; pernicious anemia; graves disease; scleroderma; inflammatory response; immune dysregulation; oral squamous cell carcinoma; cancer prognosis; sjoegren syndrome; adjuvant chemoradiotherapy; humans; prognosis; human; male; female; article; wegener granulomatosis; ankylosing spondylitis; squamous cell carcinoma of head and neck; addison disease; distant recurrence free survival |
| Journal Title: | Journal of Surgical Oncology |
| Volume: | 126 |
| Issue: | 7 |
| ISSN: | 0022-4790 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2022-12-01 |
| Start Page: | 1183 |
| End Page: | 1190 |
| Language: | English |
| DOI: | 10.1002/jso.27017 |
| PUBMED: | 35870114 |
| PROVIDER: | scopus |
| PMCID: | PMC9613520 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2022 -- Source: Scopus |
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