Effectiveness of MRNA booster vaccine among healthcare workers in New York City during the Omicron surge, December 2021 to January 2022 Journal Article
| Authors: | Robilotti, E. V.; Whiting, K.; Lucca, A.; Poon, C.; Jani, K.; McMillen, T.; Freeswick, S.; Korenstein, D.; Babady, N. E.; Seshan, V. E.; Kamboj, M. |
| Article Title: | Effectiveness of MRNA booster vaccine among healthcare workers in New York City during the Omicron surge, December 2021 to January 2022 |
| Abstract: | Objective: To describe effectiveness of mRNA vaccines by comparing 2-dose (2D) and 3-dose (3D) healthcare worker (HCW) recipients in the setting of Omicron variant dominance. Performance of 2D and 3D vaccine series against SARS-CoV-2 variants and the clinical outcomes of HCWs may inform return-to-work guidance. Methods: In a retrospective study from December 15, 2020 to January 15, 2022, SARS-CoV-2 infections among HCWs at a large tertiary cancer centre in New York City were examined to estimate infection rates (aggregated positive tests / person-days) and 95% CIs over the Omicron period in 3D and 2D mRNA vaccinated HCWs and were compared using rate ratios. We described the clinical features of post-vaccine infections and impact of prior (pre-Omicron) COVID infection on vaccine effectiveness. Results: Among the 20857 HCWs in our cohort, 20,660 completed the 2D series with an mRNA vaccine during our study period and 12461 had received a third dose by January 15, 2022. The infection rate ratio for 3D versus 2D vaccinated HCWs was 0.667 (95% CI 0.623, 0.713) for an estimated 3D vaccine effectiveness of 33.3% compared to two doses only during the Omicron dominant period from December 15, 2021 to January 15, 2022. Breakthrough Omicron infections after 3D + 14 days occurred in 1,315 HCWs. Omicron infections were mild, with 16% of 3D and 11% 2D HCWs being asymptomatic. Discussion: Study demonstrates improved vaccine-derived protection against COVID-19 infection in 3D versus 2D mRNA vaccinees during the Omicron surge. The advantage of 3D vaccination was maintained irrespective of prior COVID-19 infection status. © 2022 European Society of Clinical Microbiology and Infectious Diseases |
| Keywords: | sars-cov-2; vaccine effectiveness; booster breakthrough infections |
| Journal Title: | Clinical Microbiology and Infection |
| Volume: | 28 |
| Issue: | 12 |
| ISSN: | 1198-743X |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-12-01 |
| Start Page: | 1624 |
| End Page: | 1628 |
| Language: | English |
| DOI: | 10.1016/j.cmi.2022.07.017 |
| PUBMED: | 35931373 |
| PROVIDER: | scopus |
| PMCID: | PMC9345790 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2022 -- Source: Scopus |
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