Genomic profiling for clinical decision making in lymphoid neoplasms Journal Article
| Authors: | de Leval, L.; Alizadeh, A. A.; Bergsagel, P. L.; Campo, E.; Davies, A.; Dogan, A.; Fitzgibbon, J.; Horwitz, S. M.; Melnick, A. M.; Morice, W. G.; Morin, R. D.; Nadel, B.; Pileri, S. A.; Rosenquist, R.; Rossi, D.; Salaverria, I.; Steidl, C.; Treon, S. P.; Zelenetz, A. D.; Advani, R. H.; Allen, C. E.; Ansell, S. M.; Chan, W. C.; Cook, J. R.; Cook, L. B.; d'Amore, F.; Dirnhofer, S.; Dreyling, M.; Dunleavy, K.; Feldman, A. L.; Fend, F.; Gaulard, P.; Ghia, P.; Gribben, J. G.; Hermine, O.; Hodson, D. J.; Hsi, E. D.; Inghirami, G.; Jaffe, E. S.; Karube, K.; Kataoka, K.; Klapper, W.; Kim, W. S.; King, R. L.; Ko, Y. H.; LaCasce, A. S.; Lenz, G.; Martin-Subero, J. I.; Piris, M. A.; Pittaluga, S.; Pasqualucci, L.; Quintanilla-Martinez, L.; Rodig, S. J.; Rosenwald, A.; Salles, G. A.; San-Miguel, J.; Savage, K. J.; Sehn, L. H.; Semenzato, G.; Staudt, L. M.; Swerdlow, S. H.; Tam, C. S.; Trotman, J.; Vose, J. M.; Weigert, O.; Wilson, W. H.; Winter, J. N.; Wu, C. J.; Zinzani, P. L.; Zucca, E.; Bagg, A.; Scott, D. W. |
| Article Title: | Genomic profiling for clinical decision making in lymphoid neoplasms |
| Abstract: | With the introduction of large-scale molecular profiling methods and high-throughput sequencing technologies, the genomic features of most lymphoid neoplasms have been characterized at an unprecedented scale. Although the principles for the classification and diagnosis of these disorders, founded on a multidimensional definition of disease entities, have been consolidated over the past 25 years, novel genomic data have markedly enhanced our understanding of lymphomagenesis and enriched the description of disease entities at the molecular level. Yet, the current diagnosis of lymphoid tumors is largely based on morphological assessment and immunophenotyping, with only few entities being defined by genomic criteria. This paper, which accompanies the International Consensus Classification of mature lymphoid neoplasms, will address how established assays and newly developed technologies for molecular testing already complement clinical diagnoses and provide a novel lens on disease classification. More specifically, their contributions to diagnosis refinement, risk stratification, and therapy prediction will be considered for the main categories of lymphoid neoplasms. The potential of whole-genome sequencing, circulating tumor DNA analyses, single-cell analyses, and epigenetic profiling will be discussed because these will likely become important future tools for implementing precision medicine approaches in clinical decision making for patients with lymphoid malignancies. © 2022 The American Society of Hematology |
| Keywords: | note; clinical practice; mantle cell lymphoma; multiple myeloma; waldenstroem macroglobulinemia; dna methylation; prediction; b cell lymphoma; peripheral t cell lymphoma; lymphoma; consensus development; clinical decision making; chronic lymphatic leukemia; marginal zone lymphoma; burkitt lymphoma; personalized medicine; anaplastic large cell lymphoma; diffuse large b cell lymphoma; high throughput sequencing; human; whole genome sequencing; circulating tumor dna; dendritic cell sarcoma; liquid biopsy; lymphocytic lymphoma; protein fingerprinting; chloroplast dna; mediastinal lymphoma; adult t cell leukemia |
| Journal Title: | Blood |
| Volume: | 140 |
| Issue: | 21 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2022-11-24 |
| Start Page: | 2193 |
| End Page: | 2227 |
| Language: | English |
| DOI: | 10.1182/blood.2022015854 |
| PUBMED: | 36001803 |
| PROVIDER: | scopus |
| PMCID: | PMC9837456 |
| DOI/URL: | |
| Notes: | Note -- Export Date: 1 December 2022 -- Source: Scopus |
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