Disparities in primary breast cancer stage at presentation among Hispanic subgroups Journal Article
| Authors: | Swami, N.; Nguyen, T.; Dee, E. C.; Franco, I.; Baez, Y. A.; Lapen, K.; Wang, L.; Goel, N.; Mahal, B. A.; Fayanju, O. M.; Duma, N.; Chino, F. |
| Article Title: | Disparities in primary breast cancer stage at presentation among Hispanic subgroups |
| Abstract: | Background: Although the United States (US) Hispanic population consists of diverse communities, prior breast cancer studies often analyze this group in aggregate. Our aim was to identify differences in breast cancer stage at presentation in the US population, with a particular focus on Hispanic subgroups. Methods: Data from the National Cancer Database (NCDB) from 2004 to 2017 were used to select women with primary breast cancer; individuals were disaggregated by racial and ethnic subgroup and Hispanic country of origin. Ordinal logistic regression was used to create adjusted odds ratios (aORs) with 95% confidence intervals (CIs), with higher odds representing presentation at later-stage breast cancer. Subgroup analysis was conducted based on tumor receptor status. Results: Overall, among 2,282,691 women (5.2% Hispanic), Hispanic women were more likely to live in low-income and low-educational attainment neighborhoods, and were also more likely to be uninsured. Hispanic women were also more likely to present at later-stage primary breast cancer when compared with non-Hispanic White women (aOR 1.19, 95% CI 1.18–1.21; p < 0.01). Stage disparities were demonstrated when populations were disaggregated by country of origin, particularly for Mexican women (aOR 1.55, 95% CI 1.51–1.60; p < 0.01). Disparities worsened among both racial and country of origin subgroups in women with triple-negative disease. Conclusion: Later breast cancer stage at presentation was observed among Hispanic populations when disaggregated by racial subgroup and country of origin. Socioeconomic disparities, as well as uncaptured disparities in access and/or differential care, may drive these observed differences. Future studies with disaggregated data are needed to characterize outcomes in Hispanic communities and develop targeted interventions. © 2022, Society of Surgical Oncology. |
| Keywords: | adult; controlled study; aged; middle aged; primary tumor; major clinical study; united states; cancer staging; breast cancer; pathology; breast neoplasms; medicaid; breast tumor; comorbidity; delayed diagnosis; epidemiology; educational status; ethnicity; health disparity; caucasian; hispanic; american indian; pacific islander; health care disparity; asian; lowest income group; triple negative breast cancer; healthcare disparities; ancestry group; charlson comorbidity index; humans; human; female; article; black person; puerto rican; medically uninsured; mexican; racial groups; dominican (dominican republic); household income; hispanic or latino; native hawaiian; central american; cuban; neighborhood characteristic; south american |
| Journal Title: | Annals of Surgical Oncology |
| Volume: | 29 |
| Issue: | 13 |
| ISSN: | 1068-9265 |
| Publisher: | Springer |
| Date Published: | 2022-12-01 |
| Start Page: | 7977 |
| End Page: | 7987 |
| Language: | English |
| DOI: | 10.1245/s10434-022-12302-9 |
| PUBMED: | 35953743 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2022 -- Source: Scopus |
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