Synapse - Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis

Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis Journal Article

Authors:	Van Egeren, D.; Kohli, K.; Warner, J. L.; Bedard, P. L.; Riely, G.; Lepisto, E.; Schrag, D.; LeNoue-Newton, M.; Catalano, P.; Kehl, K. L.; Michor, F.; or the AACR Project GENIE Consortium represented by Shawn Sweeney
Contributors:	Arcila, M. E.; Benayed, R.; Berger, M. F.; Bhuiya, M.; Brannon, A. R.; Brown, S.; Chakravarty, D.; Chu, C.; de Bruijn, I.; Galle, J.; Gao, J.; Gardos, S.; Gross, B.; Kundra, R.; Kung, A. L.; Ladanyi, M.; Lavery, J. A.; Li, X.; Lisman, A.; Mastrogiacomo, B.; McCarthy, C.; Nichols, C.; Ochoa, A.; Panageas, K. S.; Philip, J.; Pillai, S.; Rizvi, H.; Rudolph, J.; Sawyers, C. L.; Schultz, N.; Schwartz, J.; Sheridan, R.; Solit, D.; Wang, A.; Wilson, M.; Zehir, A.; Zhang, H.; Zhao, G.
Article Title:	Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis
Abstract:	Patients with non-small cell lung cancer (NSCLC) who have distant metastases have a poor prognosis. To determine which genomic factors of the primary tumor are associated with metastasis, we analyzed data from 759 patients originally diagnosed with stage I–III NSCLC as part of the AACR Project GENIE Biopharma Collaborative consortium. We found that TP53 mutations were significantly associated with the development of new distant metastases. TP53 mutations were also more prevalent in patients with a history of smoking, suggesting that these patients may be at increased risk for distant metastasis. Our results suggest that additional investigation of the optimal management of patients with early-stage NSCLC harboring TP53 mutations at diagnosis is warranted in light of their higher likelihood of developing new distant metastases. © 2022, The Author(s).
Keywords:	genetics; mutation; carcinoma, non-small-cell lung; lung neoplasms; pathology; protein p53; lung tumor; tumor suppressor protein p53; genomics; tp53 protein, human; non small cell lung cancer; humans; prognosis; human
Journal Title:	Scientific Reports
Volume:	12
ISSN:	2045-2322
Publisher:	Nature Publishing Group
Date Published:	2022-11-09
Start Page:	19055
Language:	English
DOI:	10.1038/s41598-022-21448-1
PUBMED:	36351964
PROVIDER:	scopus
PMCID:	PMC9646734
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85141486603&doi=10.1038%2fs41598-022-21448-1&partnerID=40&md5=df51872ecd00c6ec18af0f425627f47b
Notes:	Article -- Export Date: 1 December 2022 -- Source: Scopus