Substantial external dose rate variability observed in a cohort of Lu-177 patients independent of BMI and sex Journal Article

   


Authors: Bellamy, M.; Chu, B.; Serencsits, B.; Quinn, B.; Prasad, K.; Altamirano, J.; Williamson, M.; Miodownik, D.; Abrahams, N.; Chen, F.; Bierman, D.; Wutkowski, M.; Dauer, L.
Article Title: Substantial external dose rate variability observed in a cohort of Lu-177 patients independent of BMI and sex
Abstract: External dose rates were measured 1 m away from 230 Lu-177 patients to characterise the variability in normalised dose rates as a function of administered activity, body mass index (BMI) and sex. The largest dose rate observed was 0.07 mSv/h associated with an administered activity of 7.2 GBq. Substantial variability was found in the distribution of the normalised dose rate associated that had an average of 0.0037 mSv/h per GBq and a 95% confidence interval of 0.0024-0.0058 mSv/h per GBq. Based on this study, estimating the patient dose rate based on the Lu-177 gamma exposure factor overestimates the dose rate by a factor of 2. A statistically significant inverse relationship was found between the patient dose rate and patient BMI and an empirically derived equation relating these two quantities was reported. On average, male patient dose rates were 3.5% lower than female dose rates, which may be attributed to the larger average BMI of the male patient group. © The Author(s) 2022. Published by Oxford University Press.
Keywords: cohort studies; cohort analysis; body mass; body mass index; radioisotope; radioisotopes; lutetium; lutetium-177; humans; human; male; female
Journal Title: Radiation Protection Dosimetry
Volume: 198
Issue: 19
ISSN: 0144-8420
Publisher: Oxford University Press  
Date Published: 2022-11-01
Start Page: 1476
End Page: 1482
Language: English
DOI: 10.1093/rpd/ncac187
PUBMED: 36138119
PROVIDER: scopus
PMCID: PMC9667277
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85142400540&doi=10.1093%2frpd%2fncac187&partnerID=40&md5=8fdd4252e0ce47df209454a5d0779ce4
Notes: Article -- Export Date: 1 December 2022 -- Source: Scopus
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MSK Authors
  1. Lawrence Dauer
    171 Dauer
  2. Matthew Williamson
    27 Williamson
  3. Brian Quinn
    20 Quinn
  4. Daniel Brett Jacob Miodownik
    11 Miodownik
  5. Bae Philavan Chu
    20 Chu
  6. Brian Ernest Serencsits
    11 Serencsits
  7. Michael John Wutkowski
    3 Wutkowski
  8. Michael B. Bellamy
    18 Bellamy
  9. Kavya Prasad
    8 Prasad
  10. David Allen Bierman
    6 Bierman
  11. Joaquin Altamirano
    4 Altamirano
  12. Fanny Chen
    2 Chen
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