Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer Journal Article
| Authors: | Damrauer, J. S.; Beckabir, W.; Klomp, J.; Zhou, M.; Plimack, E. R.; Galsky, M. D.; Grivas, P.; Hahn, N. M.; O’Donnell, P. H.; Iyer, G.; Quinn, D. I.; Vincent, B. G.; Quale, D. Z.; Wobker, S. E.; Hoadley, K. A.; Kim, W. Y.; Milowsky, M. I. |
| Article Title: | Collaborative study from the Bladder Cancer Advocacy Network for the genomic analysis of metastatic urothelial cancer |
| Abstract: | Urothelial Cancer - Genomic Analysis to Improve Patient Outcomes and Research (NCT02643043), UC-GENOME, is a genomic analysis and biospecimen repository study in 218 patients with metastatic urothelial carcinoma. Here we report on the primary outcome of the UC-GENOME—the proportion of subjects who received next generation sequencing (NGS) with treatment options—and present the initial genomic analyses and clinical correlates. 69.3% of subjects had potential treatment options, however only 5.0% received therapy based on NGS. We found an increased frequency of TP53E285K mutations as compared to non-metastatic cohorts and identified features associated with benefit to chemotherapy and immune checkpoint inhibition, including: Ba/Sq and Stroma-rich subtypes, APOBEC mutational signature (SBS13), and inflamed tumor immune phenotype. Finally, we derive a computational model incorporating both genomic and clinical features predictive of immune checkpoint inhibitor response. Future work will utilize the biospecimens alongside these foundational analyses toward a better understanding of urothelial carcinoma biology. © 2022, The Author(s). |
| Keywords: | cancer chemotherapy; controlled study; aged; primary tumor; gene mutation; major clinical study; genetics; mutation; clinical feature; chemotherapy; genetic analysis; phenotype; immune system; prevalence; cohort analysis; pathology; inhibitor; bladder tumor; urinary bladder neoplasms; drug response; urinary bladder; genomics; tumor immunity; tumor; carcinoma, transitional cell; computer model; transitional cell carcinoma; bladder; tumor microenvironment; immune checkpoint inhibitor; high throughput sequencing; high-throughput nucleotide sequencing; dna sequencing; cancer; humans; human; male; female; article; rna sequencing; oncogenomics; apolipoprotein b mrna editing enzyme catalytic polypeptide like; memory b lymphocyte |
| Journal Title: | Nature Communications |
| Volume: | 13 |
| ISSN: | 2041-1723 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2022-11-04 |
| Start Page: | 6658 |
| Language: | English |
| DOI: | 10.1038/s41467-022-33980-9 |
| PUBMED: | 36333289 |
| PROVIDER: | scopus |
| PMCID: | PMC9636269 |
| DOI/URL: | |
| Notes: | PDF shortens the author: Gopakumar Iye's first name to: Gopa -- Source: Scopus |
