Genomic determinants of early recurrences in low-stage, low-grade endometrioid endometrial carcinoma Journal Article


Authors: Safdar, N. S.; Stasenko, M.; Selenica, P.; Martin, A. S.; da Silva, E. M.; Sebastiao, A. P. M.; Krystel-Whittemore, M.; Abu-Rustum, N. R.; Reis-Filho, J. S.; Soslow, R. A.; Shen, R.; Mueller, J. J.; Oliva, E.; Weigelt, B.
Article Title: Genomic determinants of early recurrences in low-stage, low-grade endometrioid endometrial carcinoma
Abstract: Low-stage, low-grade endometrioid endometrial carcinoma (EEC), the most common histologic type of endometrial cancer, typically has a favorable prognosis. A subset of these cancers, however, displays an aggressive clinical course with early recurrences, including distant relapses. All statistical tests were 2-sided. Using a combination of whole-exome and targeted capture sequencing of 65 FIGO stage IA and IB grade 1 EECs treated with surgery alone, we demonstrate that chromosome 1q gain (odds ratio [OR] = 8.09, 95% confidence interval [CI] = 1.59 to 54.6; P = .02), PIK3CA mutation (OR = 9.16, 95% CI = 1.95 to 61.8; P = .01), and DNA mismatch repair-deficient molecular subtype (OR = 7.92, 95% CI = 1.44 to 87.6; P = .02) are independent predictors of early recurrences within 3 years in this patient population. Chromosome 1q gain was validated in an independent dataset of stage I grade 1 EECs subjected to whole-exome sequencing. Our findings expand on the repertoire of genomic parameters that should be considered in the evaluation of patients with low-stage, low-grade EEC. © The Author(s) 2022. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.
Keywords: genetics; cancer staging; endometrioid carcinoma; endometrial neoplasms; neoplasm staging; neoplasm recurrence, local; pathology; tumor recurrence; genomics; endometrium tumor; carcinoma, endometrioid; humans; prognosis; human; female
Journal Title: JNCI: Journal of the National Cancer Institute
Volume: 114
Issue: 11
ISSN: 0027-8874
Publisher: Oxford University Press  
Date Published: 2022-11-01
Start Page: 1545
End Page: 1548
Language: English
DOI: 10.1093/jnci/djac119
PUBMED: 35699480
PROVIDER: scopus
PMCID: PMC9664177
DOI/URL:
Notes: Article -- Export Date: 1 December 2022 -- Source: Scopus
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