XL-ing at induction of apoptosis in kidney cancer through inhibition of BCL-X(L) Editorial
| Authors: | Wang, N.; Hakimi, A. A.; Chen, Y. |
| Title: | XL-ing at induction of apoptosis in kidney cancer through inhibition of BCL-X(L) |
| Abstract: | Through analysis of the cancer dependency map of CRISPR and short hairpin RNA datasets, the antiapoptotic BCL-XL was found to be a selective dependency in kidney cancer. Among kidney cancers, BCL-XL inhibition is most active in those with a mesenchymal gene signature, which portends a poor prognosis and response to current therapies. © 2022 American Association for Cancer Research. |
| Keywords: | genetics; metabolism; apoptosis; small interfering rna; rna, small interfering; bcl-x protein; kidney neoplasms; kidney tumor; protein bcl x; humans; human |
| Journal Title: | Clinical Cancer Research |
| Volume: | 28 |
| Issue: | 21 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 2022-11-01 |
| Start Page: | 4600 |
| End Page: | 4602 |
| Language: | English |
| DOI: | 10.1158/1078-0432.Ccr-22-2104 |
| PUBMED: | 35984355 |
| PROVIDER: | scopus |
| PMCID: | PMC9633424 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 December 2022 -- Source: Scopus |
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