Use of nanoparticulate systems to salvage the myocardium Book Section
| Authors: | Aieneravaie, M.; Ho, J. Q.; Arabi, L.; Lee, J.; Herrera, K.; Mehreen, S.; Javdani, N.; Georgala, P.; Sepand, M. R.; Rafat, M.; Zanganeh, S. |
| Editor: | Mahmoudi, M. |
| Article/Chapter Title: | Use of nanoparticulate systems to salvage the myocardium |
| Abstract: | When the heart can no longer meet the body’s demands by providing sufficient blood pressure and/or flow, heart failure arises. The body responds to this failure, such as releasing neurohormones that stimulate the organs, retaining salt and water by the kidneys, and changing cellular and organ structure and function by activating intracellular signaling pathways in the vasculature and heart. At first, lower cardiac performance can be counteracted by these “compensatory” responses. However, these responses eventually contribute to disease progression by raising the probability of organ failure and exacerbating clinical prognosis. Heart failure may present with many variations in clinical presentation, but some symptoms are common, such as fatigue, fluid retention, and shortness of breath. Systolic heart failure (dilated heart and contractile failure) occurs in approximately 50% of all people. Diastolic heart failure (heart failure with a preserved ejection fraction (HFpEF)) comprises the other 50% and usually presents with a hypertrophied, nondilated heart which contracts normally. There is a rise in the worldwide prevalence of HFpEF, but the condition has not been well-investigated. © 2020 Elsevier Inc. All rights reserved. |
| Keywords: | fibrosis; heart failure; myocardium; matrix; elasticity; reservoir |
| Book Title: | Nanomedicine for Ischemic Cardiomyopathy: Progress, Opportunities, and Challenges |
| ISBN: | 978-0-12-817434-0 |
| Publisher: | Academic Press |
| Publication Place: | Philadelphia, PA |
| Date Published: | 2020-01-01 |
| Start Page: | 89 |
| End Page: | 111 |
| Language: | English |
| DOI: | 10.1016/b978-0-12-817434-0.00007-6 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter: 7 -- Export Date: 1 December 2022 -- Source: Scopus |
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