Synthetic introns enable highly specific targeting of cancer cells Editorial
| Authors: | Abdel-Wahab, O.; Bradley, R. K. |
| Title: | Synthetic introns enable highly specific targeting of cancer cells |
| Abstract: | A new method uses synthetic introns to express therapeutic proteins selectively in cells bearing cancer-initiating mutations affecting RNA splicing factors, while healthy cells remain unaffected. This approach enabled the eradication of human leukemia, breast cancer and uveal melanoma cells in mouse models and significantly prolonged host survival. |
| Journal Title: | Nature Biotechnology |
| Volume: | 40 |
| Issue: | 7 |
| ISSN: | 1087-0156 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2022-07-01 |
| Start Page: | 1009 |
| End Page: | 1010 |
| Language: | English |
| ACCESSION: | WOS:000826092000013 |
| DOI: | 10.1038/s41587-022-01235-z |
| PROVIDER: | wos |
| PUBMED: | 35246667 |
| Notes: | Editorial Material -- Source: Wos |
