A review of immune checkpoint blockade for the general surgeon Review
| Authors: | Baldwin, X. L.; Spanheimer, P. M.; Downs-Canner, S. |
| Review Title: | A review of immune checkpoint blockade for the general surgeon |
| Abstract: | The immune system is a complex and interconnected system that has evolved to protect its host from foreign pathogens. CD8+ T cells are a type of immune cell that can be directly lethal to tumor cells. However, their tumor killing capabilities can be inhibited by checkpoint molecules. During the last decade, the development of medications that block these checkpoint molecules has revolutionized treatment for some cancer types and indications for use continue to grow. As usage of immunotherapy increases, toxicities and adverse events unique to immunotherapy are becoming more prevalent. Here, we review the commonly targeted inhibitory molecules along with their food and drug administration-approved indications in various cancer therapeutic regimens, immunotherapy-related toxicities, and how this may impact surgical planning. © 2022 Elsevier Inc. |
| Keywords: | treatment response; cancer surgery; unclassified drug; human cell; review; hepatitis; diarrhea; liver cell carcinoma; drug approval; neoadjuvant therapy; t lymphocyte; cancer immunotherapy; melanoma; myalgia; peripheral neuropathy; food and drug administration; psoriasis; renal cell carcinoma; arthralgia; pneumonia; pruritus; rash; immunotherapy; head and neck cancer; early cancer; mismatch repair; microsatellite instability; membrane protein; cytotoxic t lymphocyte; retinopathy; colitis; autoimmune hemolytic anemia; rheumatoid arthritis; drug monitoring; hypothyroidism; cytotoxic t lymphocyte antigen 4; encephalitis; myasthenia gravis; insulin dependent diabetes mellitus; dry eye; transitional cell carcinoma; thrombotic thrombocytopenic purpura; adverse drug reaction; urticaria; pyoderma gangrenosum; xerosis; adult respiratory distress syndrome; small cell lung cancer; drug indication; hyperhidrosis; hemophilia a; hypoparathyroidism; uveitis; programmed death 1 ligand 1; programmed death 1 receptor; interstitial pneumonia; allergic pneumonitis; futurology; non small cell lung cancer; adrenal insufficiency; t cell; hypophysitis; vitiligo; myositis; cerebellar ataxia; vasculitis; lupus like syndrome; lupus erythematosus nephritis; guillain barre syndrome; autoimmune thrombocytopenia; bronchiolitis obliterans organizing pneumonia; lung sarcoidosis; immune checkpoint inhibitor; non melanoma skin cancer; bullous dermatitis; human; programmed death 1 ligand 2; interstitial nephritis; neuromuscular junction disorder; monoclonal antibody therapy; malignant neoplasm; cytotoxic t cell; checkpoint inhibition; immune checkpoint protein; acute liver failure; lymphocyte activation gene 3 |
| Journal Title: | Journal of Surgical Research |
| Volume: | 281 |
| ISSN: | 0022-4804 |
| Publisher: | Academic Press Inc., Elsevier Science |
| Date Published: | 2023-01-01 |
| Start Page: | 289 |
| End Page: | 298 |
| Language: | English |
| DOI: | 10.1016/j.jss.2022.08.040 |
| PUBMED: | 36228339 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Corresponding author is MSK author Stephanie Downs-Canner -- Export Date: 1 November 2022 -- Source: Scopus |
