| Authors: |
Mlecnik, B.; Torigoe, T.; Bindea, G.; Popivanova, B.; Xu, M.; Fujita, T.; Hazama, S.; Suzuki, N.; Nagano, H.; Okuno, K.; Hirohashi, Y.; Furuhata, T.; Takemasa, I.; Patel, P.; Vora, H.; Shah, B.; Patel, J. B.; Rajvik, K. N.; Pandya, S. J.; Shukla, S. N.; Wang, Y.; Zhang, G.; Yoshino, T.; Taniguchi, H.; Bifulco, C.; Lugli, A.; Lee, J. K. J.; Zlobec, I.; Rau, T. T.; Berger, M. D.; Nagtegaal, I. D.; Vink-Börger, E.; Hartmann, A.; Geppert, C. I.; Kolwelter, J.; Merkel, S.; Grützmann, R.; Van den Eynde, M.; Jouret-Mourin, A.; Kartheuser, A.; Léonard, D.; Remue, C.; Wang, J.; Bavi, P.; Roehrl, M. H. A.; Ohashi, P. S.; Nguyen, L. T.; Han, S.; MacGregor, H. L.; Hafezi-Bakhtiari, S.; Wouters, B. G.; Masucci, G. V.; Andersson, E.; Zavadova, E.; Vocka, M.; Spacek, J.; Petruzelka, L.; Konopasek, B.; Dundr, P.; Skalova, H.; Nemejcova, K.; Botti, G.; Tatangelo, F.; Delrio, P.; Ciliberto, G.; Maio, M.; Laghi, L.; Grizzi, F.; Marliot, F.; Fredriksen, T.; Buttard, B.; Lafontaine, L.; Maby, P.; Majdi, A.; Hijazi, A.; El Sissy, C.; Kirilovsky, A.; Berger, A.; Lagorce, C.; Paustian, C.; Ballesteros-Merino, C.; Dijkstra, J.; Van de Water, C.; van Lent-van Vliet, S.; Knijn, N.; Mușină, A. M.; Scripcariu, D. V.; Marincola, F. M.; Ascierto, P. A.; Fox, B. A.; Pagès, F.; Kawakami, Y.; Galon, J. |
| Article Title: |
Clinical performance of the consensus Immunoscore in colon cancer in the Asian population from the multicenter international SITC study |
| Abstract: |
BACKGROUND: In this study, we evaluated the prognostic value of Immunoscore in patients with stage I–III colon cancer (CC) in the Asian population. These patients were originally included in an international study led by the Society for Immunotherapy of Cancer (SITC) on 2681 patients with AJCC/UICC-TNM stages I–III CC. METHODS: CD3+ and cytotoxic CD8+ T-lymphocyte densities were quantified in the tumor and invasive margin by digital pathology. The association of Immunoscore with prognosis was evaluated for time to recurrence (TTR), disease-free survival (DFS), and overall survival (OS). RESULTS: Immunoscore stratified Asian patients (n = 423) into different risk categories and was not impacted by age. Recurrence-free rates at 3 years were 78.5%, 85.2%, and 98.3% for a Low, Intermediate, and High Immunoscore, respectively (HR[Low-vs-High] = 7.26 (95% CI 1.75−30.19); p = 0.0064). A High Immunoscore showed a significant association with prolonged TTR, OS, and DFS (p < 0.05). In Cox multivariable analysis stratified by center, Immunoscore association with TTR was independent (HR[Low-vs-Int+High] = 2.22 (95% CI 1.10–4.55) p = 0.0269) of the patient’s gender, T-stage, N-stage, sidedness, and MSI status. A significant association of a High Immunoscore with prolonged TTR was also found among MSS (HR[Low-vs-Int+High] = 4.58 (95% CI 2.27−9.23); p ≤ 0.0001), stage II (HR[Low-vs-Int+High] = 2.72 (95% CI 1.35−5.51); p = 0.0052), low-risk stage-II (HR[Low-vs-Int+High] = 2.62 (95% CI 1.21−5.68); p = 0.0146), and high-risk stage II patients (HR[Low-vs-Int+High] = 3.11 (95% CI 1.39−6.91); p = 0.0055). CONCLUSION: A High Immunoscore is significantly associated with the prolonged survival of CC patients within the Asian population. © 2022 by the authors. |
| Keywords: |
adult; cancer survival; controlled study; human tissue; aged; major clinical study; overall survival; cancer recurrence; cancer patient; disease free survival; cancer staging; cd8+ t lymphocyte; cancer immunotherapy; consensus; classification; cohort analysis; prediction; risk assessment; confidence interval; population research; proportional hazards model; immune response; multicenter study; colon cancer; cytotoxic t lymphocyte; risk stratification; medical society; multivariate analysis; age distribution; cancer classification; gender; cd3+ t lymphocyte; univariate analysis; msi; t cell; tumor microenvironment; asian; clinical outcome; confounding variable; prognostic markers; cancer prognosis; immunoscore; very elderly; human; male; female; article
|
| Journal Title: |
Cancers
|
| Volume: |
14 |
| Issue: |
18 |
| ISSN: |
2072-6694 |
| Publisher: |
MDPI
|
| Date Published: |
2022-09-02 |
| Start Page: |
4346 |
| Language: |
English |
| DOI: |
10.3390/cancers14184346
|
| PROVIDER: |
scopus
|
| PMCID: |
PMC9497086
|
| PUBMED: |
36139506
|
| DOI/URL: |
|
| Notes: |
Article -- Export Date: 1 November 2022 -- Source: Scopus |
