Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants Editorial

  


Authors: Mukherjee, S.; Carrot-Zhang, J.
Title: Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants
Abstract: In this issue of Cancer Cell, Wang et al. use whole-genome sequencing of lung cancer cases and controls with East Asian ancestry to comprehensively characterize both common and rare variants that predispose to lung cancer. Their findings suggest that rare promoter variants in BRCA2 are associated with increased lung cancer risk. © 2022 Elsevier Inc.
Keywords: promoter region; single nucleotide polymorphism; exon; genetics; cancer risk; note; cancer susceptibility; genetic predisposition to disease; germ cell; lung neoplasms; genetic variability; genotype; genome-wide association study; lung cancer; brca2 protein; lung tumor; germ cells; germ line; genetic predisposition; germ-line mutation; enhancer region; non small cell lung cancer; molecular pathology; asian; germline mutation; asians; east asian; humans; human; whole genome sequencing; rna sequencing; whole exome sequencing
Journal Title: Cancer Cell
Volume: 40
Issue: 10
ISSN: 1535-6108
Publisher: Cell Press  
Date Published: 2022-10-10
Start Page: 1081
End Page: 1083
Language: English
DOI: 10.1016/j.ccell.2022.09.006
PUBMED: 36179687
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85139440425&doi=10.1016%2fj.ccell.2022.09.006&partnerID=40&md5=e508b004040626e460bde53fb01da2f1
Notes: Note -- Export Date: 1 November 2022 -- Source: Scopus
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MSK Authors
  1. Semanti Mukherjee
    50 Mukherjee
  2. Jian Carrot-Zhang
    17 Carrot-Zhang
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