Limited liver resections in the posterosuperior segments: International multicentre propensity score-matched and coarsened exact-matched analysis comparing the laparoscopic and robotic approaches Journal Article


Authors: D'Silva, M.; Han, H. S.; Liu, R.; Kingham, T. P.; Choi, G. H.; Syn, N. L. X.; Prieto, M.; Choi, S. H.; Sucandy, I.; Chiow, A. K. H.; Marino, M. V.; Efanov, M.; Lee, J. H.; Sutcliffe, R. P.; Chong, C. C. N.; Tang, C. N.; Cheung, T. T.; Pratschke, J.; Wang, X.; Park, J. O.; Chan, C. Y.; Scatton, O.; Rotellar, F.; Troisi, R. I.; D'Hondt, M.; Fuks, D.; Goh, B. K. P.; and International Robotic and Laparoscopic Liver Resection Study Group Investigators
Article Title: Limited liver resections in the posterosuperior segments: International multicentre propensity score-matched and coarsened exact-matched analysis comparing the laparoscopic and robotic approaches
Abstract: BACKGROUND: Limited liver resections (LLRs) for tumours located in the posterosuperior segments of the liver are technically demanding procedures. This study compared outcomes of robotic (R) and laparoscopic (L) LLR for tumours located in the posterosuperior liver segments (IV, VII, and VIII). METHODS: This was an international multicentre retrospective analysis of patients who underwent R-LLR or L-LLR at 24 centres between 2010 and 2019. Patient demographics, perioperative parameters, and postoperative outcomes were analysed; 1 : 3 propensity score matching (PSM) and 1 : 1 coarsened exact matching (CEM) were performed. RESULTS: Of 1566 patients undergoing R-LLR and L-LLR, 983 met the study inclusion criteria. Before matching, 159 R-LLRs and 824 L-LLRs were included. After 1 : 3 PSM of 127 R-LLRs and 381 L-LLRs, comparison of perioperative outcomes showed that median blood loss (100 (i.q.r. 40-200) versus 200 (100-500) ml; P = 0.003), blood loss of at least 500 ml (9 (7.4 per cent) versus 94 (27.6 per cent); P < 0.001), intraoperative blood transfusion rate (4 (3.1 per cent) versus 38 (10.0 per cent); P = 0.025), rate of conversion to open surgery (1 (0.8 per cent) versus 30 (7.9 per cent); P = 0.022), median duration of Pringle manoeuvre when applied (30 (20-46) versus 40 (25-58) min; P = 0.012), and median duration of operation (175 (130-255) versus 224 (155-300); P < 0.001) were lower in the R-LLR group compared with the L-LLR group. After 1 : 1 CEM of 104 R-LLRs with 104 L-LLRs, R-LLR was similarly associated with significantly reduced blood loss and a lower rate of conversion to open surgery. CONCLUSION: Based on a matched analysis of well selected patients, both robotic and laparoscopic access could be undertaken safely with good outcomes for tumours in the posterosuperior liver segments. © The Author(s) 2022. Published by Oxford University Press on behalf of BJS Society Ltd. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Keywords: retrospective studies; clinical trial; liver cell carcinoma; carcinoma, hepatocellular; liver neoplasms; laparoscopy; retrospective study; postoperative complication; postoperative complications; length of stay; multicenter study; liver tumor; hepatectomy; procedures; propensity score; humans; human; robotic surgical procedures; robot assisted surgery
Journal Title: British Journal of Surgery
Volume: 109
Issue: 11
ISSN: 0007-1323
Publisher: Oxford University Press  
Date Published: 2022-11-01
Start Page: 1140
End Page: 1149
Language: English
DOI: 10.1093/bjs/znac270
PUBMED: 36052580
PROVIDER: scopus
DOI/URL:
Notes: Article -- Export Date: 1 November 2022 -- Source: Scopus
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  1. T Peter Kingham
    609 Kingham