Association between physical activity and neoadjuvant chemotherapy completion and pathologic complete response in primary breast cancer: The CANTO study Journal Article

   

Authors:	Baker, J. L.; Di Meglio, A.; Gbenou, A. S.; El Mouhebb, M.; Iyengar, N. M.; Michiels, S.; Cottu, P.; Lerebours, F.; Coutant, C.; Lesur, A.; Tredan, O.; Vanlemmens, L.; Jouannaud, C.; Hrab, I.; Everhard, S.; Martin, A. L.; Arveux, P.; Fabrice, A.; Vaz-Luis, I.; Jones, L. W.
Article Title:	Association between physical activity and neoadjuvant chemotherapy completion and pathologic complete response in primary breast cancer: The CANTO study
Abstract:	Background Regular physical activity is associated with improved symptom control in patients with breast cancer but its association with chemotherapy completion or response is unclear. Methods Using a prospective design, 1075 breast cancer patients receiving neoadjuvant chemotherapy between March 2012 and February 2017 were studied. Physical activity was assessed using the Global Physical Activity Questionnaire [GPAQ-16], quantified in standardised MET-h/wk. Chemotherapy completion was defined as the proportion of patients completing planned treatment course, requiring dose reduction, or requiring dose delay. Response was evaluated by pathologic complete response (pCR). Associations between physical activity and primary outcomes were assessed using multivariable logistic regression models. Results There was no differences between any chemotherapy completion outcome on the basis of physical activity classification. The percent of patients not completing planned treatment was 5.7% for <= 0.33 MET-h/wk, compared with 6.8% for 0.34-16.65 MET-h/wk, and 4.6% for >= 16.6 MET-h/wk (p = 0.52). No significant relationships were observed between physical activity dose classification and pCR for the overall cohort or upon stratification by clinical subtype. Conclusion Future studies are required to further investigate the relationship between pre-treatment levels of physical activity and function on treatment completion and response in breast and other cancer populations.
Keywords:	exercise; therapy; dose-intensity
Journal Title:	British Journal of Cancer
Volume:	127
Issue:	5
ISSN:	0007-0920
Publisher:	Nature Publishing Group
Date Published:	2022-09-01
Start Page:	886
End Page:	891
Language:	English
ACCESSION:	WOS:000812487900002
DOI:	10.1038/s41416-022-01870-y
PROVIDER:	wos
PMCID:	PMC9427741
PUBMED:	35715631
Notes:	Article -- Source: Wos

https://synapse.mskcc.org/synapse/works/has_related_data_chk/198394