Breast MRI background parenchymal enhancement categorization using deep learning: Outperforming the radiologist Journal Article
| Authors: | Eskreis-Winkler, S.; Sutton, E. J.; D'Alessio, D.; Gallagher, K.; Saphier, N.; Stember, J.; Martinez, D. F.; Morris, E. A.; Pinker, K. |
| Article Title: | Breast MRI background parenchymal enhancement categorization using deep learning: Outperforming the radiologist |
| Abstract: | Background: Background parenchymal enhancement (BPE) is assessed on breast MRI reports as mandated by the Breast Imaging Reporting and Data System (BI-RADS) but is prone to inter and intrareader variation. Semiautomated and fully automated BPE assessment tools have been developed but none has surpassed radiologist BPE designations. Purpose: To develop a deep learning model for automated BPE classification and to compare its performance with current standard-of-care radiology report BPE designations. Study Type: Retrospective. Population: Consecutive high-risk patients (i.e. >20% lifetime risk of breast cancer) who underwent contrast-enhanced screening breast MRI from October 2013 to January 2019. The study included 5224 breast MRIs, divided into 3998 training, 444 validation, and 782 testing exams. On radiology reports, 1286 exams were categorized as high BPE (i.e., marked or moderate) and 3938 as low BPE (i.e., mild or minimal). Field Strength/Sequence: A 1.5 T or 3 T system; one precontrast and three postcontrast phases of fat-saturated T1-weighted dynamic contrast-enhanced imaging. Assessment: Breast MRIs were used to develop two deep learning models (Slab artificial intelligence (AI); maximum intensity projection [MIP] AI) for BPE categorization using radiology report BPE labels. Models were tested on a heldout test sets using radiology report BPE and three-reader averaged consensus as the reference standards. Statistical Tests: Model performance was assessed using receiver operating characteristic curve analysis. Associations between high BPE and BI-RADS assessments were evaluated using McNemar's chi-square test (α* = 0.025). Results: The Slab AI model significantly outperformed the MIP AI model across the full test set (area under the curve of 0.84 vs. 0.79) using the radiology report reference standard. Using three-reader consensus BPE labels reference standard, our AI model significantly outperformed radiology report BPE labels. Finally, the AI model was significantly more likely than the radiologist to assign “high BPE” to suspicious breast MRIs and significantly less likely than the radiologist to assign “high BPE” to negative breast MRIs. Data Conclusion: Fully automated BPE assessments for breast MRIs could be more accurate than BPE assessments from radiology reports. Level of Evidence: 4. Technical Efficacy Stage: 3. © 2022 International Society for Magnetic Resonance in Medicine. |
| Keywords: | adult; retrospective studies; major clinical study; nuclear magnetic resonance imaging; magnetic resonance imaging; diagnostic imaging; breast neoplasms; retrospective study; automation; high risk patient; radiologist; image enhancement; diagnostic value; contrast enhancement; artificial intelligence; breast tumor; intermethod comparison; image processing; breast mri; background parenchymal enhancement; breast magnetic resonance imaging; diagnostic test accuracy study; procedures; radiologists; humans; human; female; article; deep learning; convolutional neural network; t1 weighted imaging; cancer risk assessment; diagnostic radiologist |
| Journal Title: | Journal of Magnetic Resonance Imaging |
| Volume: | 56 |
| Issue: | 4 |
| ISSN: | 1053-1807 |
| Publisher: | Wiley Blackwell |
| Date Published: | 2022-10-01 |
| Start Page: | 1068 |
| End Page: | 1076 |
| Language: | English |
| DOI: | 10.1002/jmri.28111 |
| PUBMED: | 35167152 |
| PROVIDER: | scopus |
| PMCID: | PMC9376189 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2022 -- Source: Scopus |
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