Analysis of intent and reason for oncologic therapy administration in cancer patients admitted to the intensive care unit Journal Article
| Authors: | Shaz, D.; Pastores, S. M.; Dayal, L.; Berkowitz, J.; Kostelecky, N.; Tan, K. S.; Halpern, N. |
| Article Title: | Analysis of intent and reason for oncologic therapy administration in cancer patients admitted to the intensive care unit |
| Abstract: | Purpose: To investigate the intent of, and reason for, administration of oncologic therapies in the intensive care unit (ICU). Methods: Single center, retrospective, cohort study of patients with cancer who received oncologic therapies at a tertiary cancer center ICU between April 1, 2019 and March 31, 2020. Oncologic therapies included traditional cytotoxic chemotherapy, targeted therapy, immunotherapy, hormonal or biologic therapy directed at a malignancy and were characterized as initiation (initial administration) or continuation (part of an ongoing regimen). Results: 84 unique patients (6.8% of total ICU admissions) received oncologic therapies in the ICU; 43 (51%) had hematologic malignancies and 41 (49%) had solid tumors. The intent of oncologic therapy was palliative in 63% and curative in 27%. Twenty-two (26%) patients received initiation and 62 (74%) received continuation oncologic therapies. The intent of oncologic therapy was significantly different by regimen type (initiation vs. continuation, p = <0.0001). Initiation therapy was more commonly prescribed with curative intent and continuation therapy was more commonly administered with palliative intent (p = <0.0001). Oncologic therapies were given in the ICU mainly for an oncologic emergency (56%) and because the patients happened to be in the ICU for a non-oncologic critical illness when their oncologic therapy was due (34.5%). Conclusion: Our study provides intensivists with a better understanding of the context and intent of oncologic therapies and why these therapies are administered in the ICU. © The Author(s) 2021. |
| Keywords: | retrospective studies; chemotherapy; neoplasm; neoplasms; palliative care; cohort studies; palliative therapy; cohort analysis; retrospective study; intensive care unit; intensive care units; critical care; cancer; humans; human; oncologic therapy |
| Journal Title: | Journal of Intensive Care Medicine |
| Volume: | 37 |
| Issue: | 10 |
| ISSN: | 0885-0666 |
| Publisher: | Sage Publications |
| Date Published: | 2022-10-01 |
| Start Page: | 1305 |
| End Page: | 1311 |
| Language: | English |
| DOI: | 10.1177/08850666211065993 |
| PUBMED: | 34898322 |
| PROVIDER: | scopus |
| PMCID: | PMC11143967 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2022 -- Source: Scopus |
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