Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients Journal Article
| Authors: | Kühn, J. P.; Bochen, F.; Körner, S.; Schick, B.; Wagner, M.; Smola, S.; Berkó-Göttel, B.; Morris, L. G. T.; Wang, J.; Bozzato, A.; Linxweiler, M. |
| Article Title: | Podoplanin expression in lymph node metastases of head and neck cancer and cancer of unknown primary patients |
| Abstract: | Introduction: Head and neck squamous cell carcinomas (HNSCCs) are cancers with generally poor prognosis. Outcomes have not improved in decades, with more than half of the patients presenting with lymph node metastases at the time of diagnosis. A unique subtype of HNSCC, cancer of unknown primary of the head and neck (HNCUP) is associated with a poor outcome. Increased expression of the D2-40 gene (podoplanin) has been described for several human malignancies and has been associated with increased metastatic potential of cancer cells. Methods: In order to examine the role of podoplanin in lymph node metastasis of HNSCC generally and HNCUP specifically, we evaluated the prognostic impact of podoplanin expression in HNSCC- (n = 68) and HNCUP-associated lymph node metastases (n = 30). The expression of podoplanin was analyzed by immunohistochemical staining of lymph node tissue samples and correlated with clinical and histopathological data. Results: We found a non-significant tendency towards a higher podoplanin expression in HNCUP compared to HNSCC lymph node metastases and a significant correlation between a high podoplanin expression and advanced node-stage classification. Podoplanin expression had no significant impact on overall survival for both groups and did not correlate with human papillomavirus tumor status. Conclusion: Taken together, our results suggest that upregulation of podoplanin may be associated with a stimulation of lymphatic metastasis in head and neck cancer. © The Author(s) 2022. |
| Keywords: | immunohistochemistry; cancer chemotherapy; human tissue; protein expression; major clinical study; overall survival; genetics; histopathology; squamous cell carcinoma; carcinoma, squamous cell; cancer staging; outcome assessment; lymph node metastasis; lymph nodes; lymphatic metastasis; ki 67 antigen; drug effect; pathology; podoplanin; statistical analysis; head and neck neoplasms; lymph node; real time polymerase chain reaction; metastasis potential; cancer of unknown primary site; tumor growth; factual database; germany; head and neck tumor; monoclonal antibody d2-40; wart virus; neoplasms, unknown primary; head and neck squamous cell carcinoma; papillomavirus infection; the cancer genome atlas; head and neck squamous cell carcinoma (hnscc); humans; prognosis; human; male; female; article; prognostic assessment; extracapsular spread; squamous cell carcinoma of head and neck; cancer of unknown primary (cup); lymphogenic metastasis; gene expression profiling interactive analysis |
| Journal Title: | International Journal of Biological Markers |
| Volume: | 37 |
| Issue: | 3 |
| ISSN: | 0393-6155 |
| Publisher: | Wichtig Editore |
| Date Published: | 2022-09-01 |
| Start Page: | 280 |
| End Page: | 288 |
| Language: | English |
| DOI: | 10.1177/03936155221105524 |
| PUBMED: | 35880270 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2022 -- Source: Scopus |
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