The MEMORY Study: MulticentEr study of Minimally invasive surgery versus Open Radical hYsterectomy in the management of early-stage cervical cancer: Survival outcomes Journal Article
| Authors: | Leitao, M. M. Jr; Zhou, Q. C.; Brandt, B.; Iasonos, A.; Sioulas, V.; Lavigne Mager, K.; Shahin, M.; Bruce, S.; Black, D. R.; Kay, C. G.; Gandhi, M.; Qayyum, M.; Scalici, J.; Jones, N. L.; Paladugu, R.; Brown, J.; Naumann, R. W.; Levine, M. D.; Mendivil, A.; Lim, P. C.; Kang, E.; Cantrell, L. A.; Sullivan, M. W.; Martino, M. A.; Kratz, M. K.; Kolev, V.; Tomita, S.; Leath, C. A. 3rd; Boitano, T. K. L.; Doo, D. W.; Feltmate, C.; Sugrue, R.; Olawaiye, A. B.; Goldfeld, E.; Ferguson, S. E.; Suhner, J.; Abu-Rustum, N. R. |
| Article Title: | The MEMORY Study: MulticentEr study of Minimally invasive surgery versus Open Radical hYsterectomy in the management of early-stage cervical cancer: Survival outcomes |
| Abstract: | Objective: The Laparoscopic Approach to Cervical Cancer (LACC) trial found that minimally invasive radical hysterectomy compared to open radical hysterectomy compromised oncologic outcomes and was associated with worse progression-free survival (PFS) and overall survival (OS) in early-stage cervical carcinoma. We sought to assess oncologic outcomes at multiple centers between minimally invasive (MIS) radical hysterectomy and OPEN radical hysterectomy. Methods: This is a multi-institutional, retrospective cohort study of patients with 2009 FIGO stage IA1 (with lymphovascular space invasion) to IB1 cervical carcinoma from 1/2007–12/2016. Patients who underwent preoperative therapy were excluded. Squamous cell carcinoma, adenocarcinoma, and adenosquamous carcinomas were included. Appropriate statistical tests were used. Results: We identified 1093 cases for analysis—715 MIS (558 robotic [78%]) and 378. OPEN procedures. The OPEN cohort had more patients with tumors >2 cm, residual disease in the hysterectomy specimen, and more likely to have had adjuvant therapy. Median follow-up for the MIS and OPEN cohorts were 38.5 months (range, 0.03–149.51) and 54.98 months (range, 0.03–145.20), respectively. Three-year PFS rates were 87.9% (95% CI: 84.9–90.4%) and 89% (95% CI: 84.9–92%), respectively (P = 0.6). On multivariate analysis, the adjusted HR for recurrence/death was 0.70 (95% CI: 0.47–1.03; P = 0.07). Three-year OS rates were 95.8% (95% CI: 93.6–97.2%) and 96.6% (95% CI: 93.8–98.2%), respectively (P = 0.8). On multivariate analysis, the adjusted HR for death was 0.81 (95% CI: 0.43–1.52; P = 0.5). Conclusion: This multi-institutional analysis showed that an MIS compared to OPEN radical hysterectomy for cervical cancer did not appear to compromise oncologic outcomes, with similar PFS and OS. © 2022 Elsevier Inc. |
| Keywords: | adult; cancer survival; controlled study; aged; disease-free survival; retrospective studies; major clinical study; overall survival; clinical trial; cancer recurrence; squamous cell carcinoma; united states; cancer adjuvant therapy; disease free survival; cancer staging; follow up; hysterectomy; neoplasm staging; laparoscopy; adenocarcinoma; progression free survival; cohort analysis; pathology; retrospective study; cancer mortality; minimal residual disease; multicenter study; uterine cervix cancer; cancer size; intermethod comparison; minimally invasive surgery; adenosquamous carcinoma; preoperative treatment; uterine cervical neoplasms; canada; uterine cervix tumor; radical hysterectomy; uterine cervix carcinoma; cervical cancer; clinical outcome; multicenter study (topic); procedures; open surgery; lymph vessel metastasis; minimally invasive surgical procedures; humans; human; female; article; gynecologic oncologist; lacc; laparoscopic approach to cervical cancer trial; minimally invasive radical hysterectomy |
| Journal Title: | Gynecologic Oncology |
| Volume: | 166 |
| Issue: | 3 |
| ISSN: | 0090-8258 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2022-09-01 |
| Start Page: | 417 |
| End Page: | 424 |
| Language: | English |
| DOI: | 10.1016/j.ygyno.2022.07.002 |
| PUBMED: | 35879128 |
| PROVIDER: | scopus |
| PMCID: | PMC9933771 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2022 -- Source: Scopus |
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