Melanoma-specific clinical outcomes of inpatient immune checkpoint blockade treatment Journal Article
| Authors: | Loo, K.; Kalvin, H. L.; Panageas, K. S.; Park, V.; Postow, M. A. |
| Article Title: | Melanoma-specific clinical outcomes of inpatient immune checkpoint blockade treatment |
| Abstract: | BACKGROUND: Little is known about patient outcomes with advanced melanoma following inpatient initiation or continuation of immune checkpoint blockade (ICB). METHODS AND RESULTS: We conducted a single institution retrospective case series of advanced melanoma patients who initiated ICB as an inpatient (initial inpatient cohort, n = 9), or continued ICB as an inpatient after previously starting as an outpatient (outpatient then inpatient cohort, n = 5). One patient had a partial response to ICB initiated as an inpatient, but ultimately died of melanoma after 13.5 months. Median overall survival for initial inpatient cohort was 1.0 month (95% CI: 0.2-11.2), and 1.4 months (95% CI: 0.4-58.0) for the outpatient then inpatient cohort. Three patients were alive >6 months after inpatient ICB administration. CONCLUSION: Despite overall poor outcomes, some patients may benefit from inpatient ICB. This study provides additional information for clinicians to appropriately counsel patients on expectations following inpatient ICB. © The Author(s) 2022. Published by Oxford University Press. |
| Keywords: | retrospective studies; melanoma; retrospective study; immunotherapy; hospital patient; inpatients; humans; human; immune checkpoint inhibitors; inpatient treatment |
| Journal Title: | The Oncologist |
| Volume: | 27 |
| Issue: | 9 |
| ISSN: | 1083-7159 |
| Publisher: | Oxford University Press |
| Date Published: | 2022-09-01 |
| Start Page: | e755 |
| End Page: | e758 |
| Language: | English |
| DOI: | 10.1093/oncolo/oyac121 |
| PUBMED: | 35766876 |
| PROVIDER: | scopus |
| PMCID: | PMC9438908 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2022 -- Source: Scopus |
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