An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma Review
| Authors: | Shulman, D. S.; Whittle, S. B.; Surdez, D.; Bailey, K. M.; de Álava, E.; Yustein, J. T.; Shlien, A.; Hayashi, M.; Bishop, A. J. R.; Crompton, B. D.; DuBois, S. G.; Shukla, N.; Leavey, P. J.; Lessnick, S. L.; Kovar, H.; Delattre, O.; Grünewald, T. G. P.; Antonescu, C. R.; Roberts, R. D.; Toretsky, J. A.; Tirode, F.; Gorlick, R.; Janeway, K. A.; Reed, D.; Lawlor, E. R.; Grohar, P. J. |
| Review Title: | An international working group consensus report for the prioritization of molecular biomarkers for Ewing sarcoma |
| Abstract: | The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60–80% of patients with metastatic tumors suffer relapse and die of disease. In addition, those who survive are often left with debilitating late effects. Clinical features aside from stage have proven inadequate to meaningfully classify patients for risk-stratified therapy. Therefore, there is a critical need to develop approaches to risk stratify patients with EwS based on molecular features. Over the past decade, new technology has enabled the study of multiple molecular biomarkers in EwS. Preliminary evidence requiring validation supports copy number changes, and loss of function mutations in tumor suppressor genes as biomarkers of outcome in EwS. Initial studies of circulating tumor DNA demonstrated that diagnostic ctDNA burden and ctDNA clearance during induction are also associated with outcome. In addition, fusion partner should be a pre-requisite for enrollment on EwS clinical trials, and the fusion type and structure require further study to determine prognostic impact. These emerging biomarkers represent a new horizon in our understanding of disease risk and will enable future efforts to develop risk-adapted treatment. © 2022, The Author(s). |
| Keywords: | immunohistochemistry; adult; cancer survival; controlled study; event free survival; human tissue; gene mutation; exon; clinical feature; review; cancer recurrence; cancer patient; cancer staging; protein function; phenotype; dna damage; consensus; metastasis; gene amplification; tumor volume; protein p53; tumor marker; risk assessment; ewing sarcoma; tumor suppressor gene; gene rearrangement; loss of function mutation; genetic marker; copy number variation; cancer prognosis; high throughput sequencing; human; circulating tumor dna; tumor mutational burden; chloroplast dna; homeobox protein nkx-2.2 |
| Journal Title: | npj Precision Oncology |
| Volume: | 6 |
| ISSN: | 2397-768X |
| Publisher: | Springer Nature |
| Date Published: | 2022-09-17 |
| Start Page: | 65 |
| Language: | English |
| DOI: | 10.1038/s41698-022-00307-2 |
| PROVIDER: | scopus |
| PMCID: | PMC9482616 |
| PUBMED: | 36115869 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 October 2022 -- Source: Scopus |
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