Practical considerations in diagnosing and managing early-onset GI cancers Review

   


Authors: Lumish, M. A.; Cercek, A.
Review Title: Practical considerations in diagnosing and managing early-onset GI cancers
Abstract: The incidence of early-onset (EO) GI cancers occurring in individuals younger than age 50 years has been rising at an alarming rate over the past two decades. Although this rise in incidence among young patients correlates with increased rates of obesity, changes in diet, and alterations in the environment, the effects of these environmental factors on carcinogenesis, metastasis, and treatment response are unknown. Although several unique clinical trends exist among EO-GI cancers and their average-onset GI cancer counterparts, GI cancers are molecularly indistinct between younger and older patients, and no data support distinct treatment paradigms for patients with EO disease. The majority of EO-GI cancers are not explained by germline changes. There remains a critical need for further research to understand the pathogenesis and optimal management of EO-GI cancers. In addition, current screening strategies are not adequate to identify EO-GI cancers, and early biomarkers are needed. Specialized centers, with a focus on psychosocial aspects of cancer management, can address the unique care needs of patients with EO-GI cancers. © American Society of Clinical Oncology.
Keywords: middle aged; incidence; gastrointestinal neoplasms; gastrointestinal tumor; humans; human
Journal Title: Journal of Clinical Oncology
Volume: 40
Issue: 24
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2022-08-20
Start Page: 2662
End Page: 2680
Language: English
DOI: 10.1200/jco.21.02708
PUBMED: 35839438
PROVIDER: scopus
PMCID: PMC9390825
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85136479162&doi=10.1200%2fJCO.21.02708&partnerID=40&md5=b01b8423b071447a49dfd67e93b9da45
Notes: Article -- Export Date: 3 October 2022 -- Source: Scopus
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MSK Authors
  1. Andrea Cercek Hanjis
    351 Cercek Hanjis
  2. Melissa Amy Lumish
    39 Lumish
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