Underutilization of guideline-recommended mismatch repair/microsatellite instability biomarker testing in advanced colorectal cancer Journal Article


Authors: Papke, D. J. Jr; Lindeman, N. I.; Schrag, D.; Iorgulescu, J. B.
Article Title: Underutilization of guideline-recommended mismatch repair/microsatellite instability biomarker testing in advanced colorectal cancer
Abstract: Background: In 2017, DNA mismatch repair/microsatellite instability (MMR/MSI) testing was nationally recommended for advanced colorectal cancers based on favorable immune checkpoint inhibitor responses among patients with MMR-deficient/MSI-high tumors. Methods: Patients ages ≥20-years-old presenting with stage IV colorectal adenocarcinoma from 2010 to 2017 were identified from the National Cancer Database. 2017 was the latest year with available testing utilization data. Patient, tumor, socioeconomic, and care setting characteristics were evaluated for association with upfront MMR/MSI testing in 2017 using multivariable logistic regression and average adjusted predicted probabilities (%AAP). Results: Among 72,830 stage IV colorectal cancers, upfront MMR/MSI testing levels increased from 16.4% in 2010 to 56.4% in 2017. For patients diagnosed in 2017 (i.e., following national recommendations, n 1⁄4 10,022), testing levels were lower for older patients (Padj < 0.001), and were independent of patients’ race/ethnicity and insurance status. Patients from the poorest quartile of households received less testing [49.6%AAP, 99.9% confidence interval (CI) 45.5–53.7] than patients from the 3rd (56.9%AAP, 99.9% CI, 53.3–60.6; Padj < 0.001) or 4th quartiles (57.6%AAP, 99.9% CI, 54.3–60.9; Padj < 0.001). Although testing levels improved most at community programs, they remained lower in 2017 (46.6%AAP, 99.9% CI, 41.0–52.1) compared with academic/NCI-designated comprehensive cancer centers (62.8%AAP, 99.9% CI, 59.7–65.8; Padj < 0.001). Conclusions: Upfront MMR/MSI testing utilization for patients with advanced colorectal cancer has increased but there is still substantial need for optimization. Testing utilization disproportionately lagged for patients who were older, from the poorest quartile of households, or managed at community cancer programs. Impact: Our findings indicate opportunities for improving rates of MMR/MSI testing and reporting, possibly through incorporation into quality control and accreditation metrics. ©2022 American Association for Cancer Research.
Keywords: adult; controlled study; young adult; major clinical study; genetics; advanced cancer; cancer staging; adenocarcinoma; biomarkers; biological marker; cohort analysis; retrospective study; colorectal neoplasms; social status; cancer center; colorectal tumor; mismatch repair; microsatellite instability; dna mismatch repair; comorbidity; colorectal adenocarcinoma; population size; humans; human; male; female; article; household income
Journal Title: Cancer Epidemiology Biomarkers and Prevention
Volume: 31
Issue: 9
ISSN: 1055-9965
Publisher: American Association for Cancer Research  
Date Published: 2022-09-01
Start Page: 1746
End Page: 1751
Language: English
DOI: 10.1158/1055-9965.Epi-22-0279
PUBMED: 35767976
PROVIDER: scopus
PMCID: PMC9444979
DOI/URL:
Notes: Article -- Export Date: 3 October 2022 -- Source: Scopus
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  1. Deborah Schrag
    228 Schrag