A prospective study on the safety and efficacy of vascularized lymph node transplant Conference Paper
| Authors: | Brown, S.; Mehrara, B. J.; Coriddi, M.; McGrath, L.; Cavalli, M.; Dayan, J. H. |
| Title: | A prospective study on the safety and efficacy of vascularized lymph node transplant |
| Conference Title: | 141st Annual Meeting of the American Surgical Association (ASA) |
| Abstract: | Purpose: While vascularized lymph node transplant (VLNT) has gained popularity, there are a lack of prospective long-term studies and standardized outcomes. The purpose of this study was to evaluate the safety and efficacy of VLNT using all available outcome measures. Methods: This was a prospective study on all consecutive patients who underwent VLNT. Outcomes were assessed with 2 patient-reported outcome metrics, limb volume, bioimpedance, need for compression, and incidence of cellulitis. Results: There were 89 patients with the following donor sites: omentum (73%), axilla (13%), supraclavicular (7%), groin (3.5%). The mean follow-up was 23.7±12 months. There was a significant improvement at 2 years postoperatively across all outcome measures: 28.4% improvement in the Lymphedema Life Impact Scale, 20% average reduction in limb volume, 27.5% improvement in bioimpedance score, 93% reduction in cellulitis, and 34% of patients no longer required compression. Complications were transient and low without any donor site lymphedema. Conclusions: VLNT is a safe and effective treatment for lymphedema with significant benefits fully manifesting at 2 years postoperatively. Omentum does not have any donor site lymphedema risk making it an attractive first choice. © 2022 Lippincott Williams and Wilkins. All rights reserved. |
| Keywords: | adult; surgical technique; major clinical study; donor site; drug safety; outcome assessment; follow up; lymph nodes; prospective study; prospective studies; incidence; transplantation; lymphedema; body mass; limb; lymph node; compression; surgery; axilla; enoxaparin; venous thromboembolism; cellulitis; complication; omentum; patient-reported outcome; inguinal region; humans; human; male; female; article; volt; vascularized lymph node transplant; vlnt; vascularized composite allotransplantation |
| Journal Title | Annals of Surgery |
| Volume: | 276 |
| Issue: | 4 |
| Conference Dates: | 2021 Apr 14-16 |
| Conference Location: | Virtual |
| ISBN: | 0003-4932 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2022-10-01 |
| Start Page: | 635 |
| End Page: | 653 |
| Language: | English |
| DOI: | 10.1097/sla.0000000000005591 |
| PUBMED: | 35837897 |
| PROVIDER: | scopus |
| PMCID: | PMC9463125 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 3 October 2022 -- Source: Scopus |
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