The impact of anti-CD20-based therapy on hypogammaglobulinemia in patients with follicular lymphoma Journal Article
| Authors: | Fischer, T.; Ni, A.; Bantilan, K. S.; Soumerai, J. D.; Alperovich, A.; Batlevi, C.; Younes, A.; Zelenetz, A. D. |
| Article Title: | The impact of anti-CD20-based therapy on hypogammaglobulinemia in patients with follicular lymphoma |
| Abstract: | Although treatment with anti-CD20 monoclonal antibodies (mAb) has improved outcomes in B-cell malignancies, it’s associated with increased risk of hypogammaglobulinemia (HG). Our study aimed to determine the effects of anti-CD20 mAb on serum immunoglobulins (Ig) in follicular lymphoma (FL). Ig concentrations, infectious complications, and need for intravenous Ig were evaluated by level of exposure to anti-CD20 mAb in 380 patients. Prevalence of HG significantly differed by level of treatment exposure (p < 0.001). Single course anti-CD20 mAb was associated with rising IgG (+10.3 mg/dL/year), whereas the addition of maintenance therapy (−7.4 mg/dL/year) or multiple courses of treatment (−10.3 mg/dL/year) was associated with declining IgG. Among patients treated with anti-CD20 mAb, 45.2% developed IgG-HG and 10.3% developed symptomatic IgG-HG. Pretreatment IgG levels gradually declined in all patients, suggesting tumor burden may contribute to HG. Baseline and periodic monitoring of serum Ig is appropriate in patients with FL, including those managed with active surveillance. © 2021 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | adult; controlled study; human tissue; aged; major clinical study; cancer patient; rituximab; gene expression; prevalence; immunoglobulin; retrospective study; immunoglobulin g; active surveillance; cancer size; lymphoma; immunoglobulin blood level; immunoglobulin deficiency; follicular lymphoma; infectious complication; infections; cd20 antibody; hypogammaglobulinemia; human; male; female; article |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 63 |
| Issue: | 3 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2022-01-01 |
| Start Page: | 573 |
| End Page: | 582 |
| Language: | English |
| DOI: | 10.1080/10428194.2021.2010058 |
| PUBMED: | 35109746 |
| PROVIDER: | scopus |
| PMCID: | PMC10754062 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 April 2022 -- Funding text 1: This work was supported by a grant from The Bahwan Fund and The Lymphoma Research Fund (A.D.Z.). -- Source: Scopus |
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