Role of finerenone in the treatment of diabetic kidney disease: Patient selection and clinical perspectives Review
| Authors: | Shaikh, A.; Ray, J.; Campbell, K. N. |
| Review Title: | Role of finerenone in the treatment of diabetic kidney disease: Patient selection and clinical perspectives |
| Abstract: | Diabetes is the leading cause of chronic and end stage kidney disease globally. Despite recent advances in therapies for diabetic kidney disease (DKD), there remains a critical need for additional options to improve renal and cardiovascular outcomes. Mineralocorticoid overactivation contributes to inflammation and fibrosis which in turn leads to progression of DKD. Finerenone, a novel non-steroidal mineralocorticoid receptor antagonist, has shown promising cardiac and renoprotective benefits in DKD. The utility of finerenone in the real world will require appropriate patient selection and patient monitoring by clinicians. © 2022 Shaikh et al. |
| Keywords: | review; placebo; drug efficacy; drug safety; drug withdrawal; hypertension; nonhuman; patient selection; inflammation; patient monitoring; hyperkalemia; chronic kidney disease; cardiovascular disease; heart failure; diabetic nephropathy; blood pressure; spironolactone; drug dose titration; drug half life; dipeptidyl carboxypeptidase inhibitor; non insulin dependent diabetes mellitus; proteinuria; heart protection; diuretic agent; chronic kidney failure; diabetes; albuminuria; angiotensin receptor antagonist; heart muscle fibrosis; diabetic ketoacidosis; hypovolemia; renal protection; potassium blood level; kidney fibrosis; eplerenone; estimated glomerular filtration rate; phosphate binding agent; human; canagliflozin; sodium glucose cotransporter 2 inhibitor; finerenone; dapagliflozin; empagliflozin; esaxerenone; mineralocorticoid antagonist; mineralocorticoid receptor; albumin to creatinine ratio |
| Journal Title: | Therapeutics and Clinical Risk Management |
| Volume: | 18 |
| ISSN: | 1176-6336 |
| Publisher: | Dove Medical Press Ltd |
| Date Published: | 2022-01-01 |
| Start Page: | 753 |
| End Page: | 760 |
| Language: | English |
| DOI: | 10.2147/tcrm.S325916 |
| PROVIDER: | scopus |
| PMCID: | PMC9346301 |
| PUBMED: | 35937973 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 September 2022 -- Source: Scopus |
